A mathematical model for the influenza virus life cycle

被引：0

作者：

Akberdin, I. R. ^{[1
]}

Kashevarova, N. A. ^{[2
]}

Khlebodarova, T. M. ^{[1
]}

Bazhan, S., I ^{[3
]}

Likhoshvai, V. A. ^{[1
]}

机构：

[1] SB RAS, Inst Cytol & Genet, Novosibirsk 630090, Russia

[2] Novosibirsk State Univ, Novosibirsk 630090, Russia

[3] State Res Ctr Virol & Biotechnol Vector, Koltsov 633159, Russia

来源：

PROCEEDINGS OF THE FIFTH INTERNATIONAL CONFERENCE ON BIOINFORMATICS OF GENOME REGULATION AND STRUCTURE, VOL 2 | 2006年

基金：

俄罗斯基础研究基金会;

关键词：

mathematical modeling; gene network; Influenza virus; intracellular ontogeny;

D O I：

暂无

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Motivation: The Influenza virus (Vinf) is a widespread infectious agent causing contagious disease in humans and animals. Its prominent feature is high and functional genetic variability. The mechanisms underlying virus give rise to strains possessing novel unpredictable properties. Their analysis and reliable prediction are the tasks of basic and applied biogenetics and virology. The pressing question is: What may be the replication pattern of the Vinf within the infected host cell? There is, as yet, no clarity. This is a stumbling block for advancement in this research area. Results: Here, we have reconstructed the gene network and develop a mathematical model for the Vinf. They incorporate the processes of replication, transcription, translation, regulation them and assembly within the Vinf infected cell. Based on the mathematical model, we followed the dynamics of the developed gene network and analyzed the key regulatory stages of the Vinf replication.

引用

页码：105 / +

页数：2

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