TNP-470 combined with nicardipine suppresses in vivo growth of PC-3, a human prostate cancer cell line

被引：6

作者：

Arisawa, C ^{[1
]}

Kageyama, Y ^{[1
]}

Kawakami, S ^{[1
]}

Kihara, K ^{[1
]}

机构：

[1] Tokyo Med & Dent Univ, Grad Sch, Dept Urol & Reprod Med, Bunkyo Ku, Tokyo 1138519, Japan

来源：

UROLOGIC ONCOLOGY | 2002年 / 7卷 / 06期

关键词：

angiogenesis; inhibitor; prostate; neoplasm;

D O I：

10.1016/S1078-1439(02)00195-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We examined effects of TNP-470 with or without nicardipine on in vivo or in vitro growth of a hormone-independent human prostate carcinoma cell line, PC-3. TNP-470 (30 mg/kg, daily) or nicardipine (25 mug/kg, daily) alone had little effects on in vivo growth of PC-3 cells in Dude mice, whereas simultaneous administration of both agents significantly inhibited the growth of the xenografts. In vitro proliferarion of PC-3 was not affected by TNP-470 and/or nicardipin. Combination of TNP-470 and nicardipine seems beneficial in the treatment of hormone-refractory prostate cancer. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：229 / 234

页数：6

共 50 条

[31] Combined treatment with TNP-470 and 5-fluorouracil effectively inhibits growth of murine colon cancer cells in vitro and liver metastasis in vivo
Ogawa, H
Sato, Y
Kondo, M
Takahashi, N
Oshima, T
Sasaki, F
Une, Y
Nishihira, J
Todo, S
ONCOLOGY REPORTS, 2000, 7 (03) : 467 - 472
[32] Bortezomib and etoposide combinations exert synergistic effects on the human prostate cancer cell line PC-3
Aras, Bekir
Yerlikaya, Azmi
ONCOLOGY LETTERS, 2016, 11 (05) : 3179 - 3184
[33] Regulatory roles of KDR antisense oligonucleotide on the proliferation of human prostate cancer cell line PC-3
Song, Jianghong
Song, Yisheng
Guo, Wei
Jia, Junqi
Jin, Yongsheng
Bai, Ansheng
JOURNAL OF BUON, 2014, 19 (03): : 770 - 774
[34] Synergistic inhibition of tumor growth and metastasis by combined treatment with TNP-470 and gemcitabine in a human bladder cancer KoTCC-1 model
Muramaki, M
Miyake, H
Hara, I
Kawabata, G
Kamidono, S
JOURNAL OF UROLOGY, 2004, 172 (04): : 1485 - 1489
[35] Reduction of oxidative stress and ornithine decarboxylase expression in a human prostate cancer cell line PC-3 by a combined treatment with α-tocopherol and naringenin
Torricelli, Piera
Elia, Antonia Concetta
Magara, Gabriele
Feriotto, Giordana
Forni, Cinzia
Borromeo, Ilaria
De Martino, Angelo
Tabolacci, Claudio
Mischiati, Carlo
Beninati, Simone
AMINO ACIDS, 2021, 53 (01) : 63 - 72
[36] Reduction of oxidative stress and ornithine decarboxylase expression in a human prostate cancer cell line PC-3 by a combined treatment with α-tocopherol and naringenin
Piera Torricelli
Antonia Concetta Elia
Gabriele Magara
Giordana Feriotto
Cinzia Forni
Ilaria Borromeo
Angelo De Martino
Claudio Tabolacci
Carlo Mischiati
Simone Beninati
Amino Acids, 2021, 53 : 63 - 72
[37] CCL2 INCREASES IN VIVO TUMOR GROWTH OF HUMAN PROSTATE CANCER PC-3 TUMOR XENOGRAFT
Mizutani, Kosuke
Sud, Sudha
Varsos, Zachary
Roca, Hernan
Pienta, Kenneth J.
JOURNAL OF UROLOGY, 2009, 181 (04): : 264 - 264
[38] In vitro and in vivo (SCID mice) effects of phytosterols on the growth and dissemination of human prostate cancer PC-3 cells
Awad, AB
Fink, CS
Williams, H
Kim, U
EUROPEAN JOURNAL OF CANCER PREVENTION, 2001, 10 (06) : 507 - 513
[39] Angiogenesis inhibitor TNP-470 inhibits growth and metastasis of a hormone-independent rat prostatic carcinoma cell line
Miki, T
Nonomura, N
Nozawa, M
Harada, Y
Nishimura, K
Kojima, Y
Takahara, S
Okuyama, A
JOURNAL OF UROLOGY, 1998, 160 (01): : 210 - 213
[40] Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo
Srivastava, SK
Xiao, D
Lew, KL
Hershberger, P
Kokkinakis, DM
Johnson, CS
Trump, DL
Singh, SV
CARCINOGENESIS, 2003, 24 (10) : 1665 - 1670

← 1 2 3 4 5 →