Advances on N-Arylation of Indoles by Cross-Coupling Reactions

被引：20

作者：

Xu, Hui ^{[1
]}

机构：

[1] NW A&F Univ, Coll Sci, Lab Pharmaceut Synth, Yangling 712100, Peoples R China

来源：

MINI-REVIEWS IN ORGANIC CHEMISTRY | 2009年 / 6卷 / 04期

基金：

高等学校博士学科点专项科研基金;

关键词：

N-Arylindole; indole; cross-coupling; transition metal-catalyst; aromatic nucleophilic substitution reaction; AROMATIC NUCLEOPHILIC-SUBSTITUTION; NITROGEN-CONTAINING HETEROCYCLES; ARYL HALIDES; BOND FORMATION; EFFICIENT; PHENYLATION; AMIDATION; COMPLEXES; AMINATION; REAGENTS;

D O I：

10.2174/157019309789371613

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Arylindoles are known to be important subunits due to their key role in medically biological activities. This mini-review initially covers the important advances on the N-arylation of indoles with aryl halides by palladium, copper or other transition metals-catalyzed cross-coupling reactions in recent ten years. Subsequently, the synthesis of N-arylindoles from indoles with aryl halides, activated by electron-withdrawing substituents, by aromatic nucleophilic substitution reactions (SNAr) is also surveyed.

引用

页码：367 / 377

页数：11

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