Advances on N-Arylation of Indoles by Cross-Coupling Reactions

被引:20
|
作者
Xu, Hui [1 ]
机构
[1] NW A&F Univ, Coll Sci, Lab Pharmaceut Synth, Yangling 712100, Peoples R China
基金
高等学校博士学科点专项科研基金;
关键词
N-Arylindole; indole; cross-coupling; transition metal-catalyst; aromatic nucleophilic substitution reaction; AROMATIC NUCLEOPHILIC-SUBSTITUTION; NITROGEN-CONTAINING HETEROCYCLES; ARYL HALIDES; BOND FORMATION; EFFICIENT; PHENYLATION; AMIDATION; COMPLEXES; AMINATION; REAGENTS;
D O I
10.2174/157019309789371613
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
N-Arylindoles are known to be important subunits due to their key role in medically biological activities. This mini-review initially covers the important advances on the N-arylation of indoles with aryl halides by palladium, copper or other transition metals-catalyzed cross-coupling reactions in recent ten years. Subsequently, the synthesis of N-arylindoles from indoles with aryl halides, activated by electron-withdrawing substituents, by aromatic nucleophilic substitution reactions (SNAr) is also surveyed.
引用
收藏
页码:367 / 377
页数:11
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