Four-locus high-resolution HLA typing in a sample of Mexican Americans

被引：20

作者：

Klitz, W. ^{[1
,2
]}

Gragert, L. ^{[3
]}

Maiers, M. ^{[3
]}

Tu, B. ^{[4
]}

Lazaro, A. ^{[4
]}

Yang, R. ^{[4
]}

Xu, Q. ^{[4
]}

Masaberg, C. ^{[4
]}

Ng, J. ^{[4
]}

Hurley, C. K. ^{[5
]}

机构：

[1] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA

[2] Inst Publ Hlth, Oakland, CA USA

[3] Natl Marrow Donor Program, Dept Bioinformat, Minneapolis, MN USA

[4] Georgetown Univ, Dept Pediat, Washington, DC 20057 USA

[5] Georgetown Univ, Dept Oncol, Washington, DC 20057 USA

来源：

TISSUE ANTIGENS | 2009年 / 74卷 / 06期

关键词：

haplotype frequency; Mexican American; Native American; WORLDWIDE POPULATIONS; HAPLOTYPE FREQUENCIES; MOLECULAR ANALYSIS; SERI INDIANS; CLASS-I; ALLELES; HLA-DRB1; GENES; POLYMORPHISM; DIVERSITY;

D O I：

10.1111/j.1399-0039.2009.01374.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mexicans are the most common minority population of the United States. From a sample of 553 bone marrow donor registrants of self-described Mexican ancestry, human leukocyte antigen (HLA) loci A, C, B and DRB1 were typed by highresolution sequence based typing (SBT) methods. A total of 47, 34, 76 and 46 distinct alleles at A, C, B and DRB1 respectively were identified, including 3 new alleles. The four-locus haplotype frequency distribution was extremely skewed with only 53.9% of 1106 chromosomes present with more than one estimated copy. Haplotypes of Native American origin were identified. These data form an initial basis for determining the requirements for an adequate donor pool for stem cell transplantation in this population.

引用

页码：508 / 513

页数：6

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