Antimicrobial mechanism of β-glycyrrhetinic acid isolated from licorice, Glycyrrhiza glabra

被引：37
|
作者：
Kim, HK
Park, Y
Kim, HN
Choi, BH
Jeong, HG
Lee, DG
Hahm, KS
机构：
[1] Chosun Univ, Res Ctr Proteineous Mat, Kwangju 501759, South Korea
[2] Chosun Univ, Coll Pharm, Kwangju 501759, South Korea
[3] Chosun Univ, Dept Biomat, Kwangju 501759, South Korea
来源：
BIOTECHNOLOGY LETTERS | 2002年 / 24卷 / 22期
关键词：
confocal microscopy; licorice; macromolecule inhibition;
D O I：
10.1023/A:1020900124997
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
beta-Glycyrrhetinic acid isolated from Glycyrrhiza glabra had an antibacterial activity of 7.6 and 12.5 mug ml(-1) against Bacillus subtilis and Staphylococcus epidermidis without causing hemolysis of human erythrocytes, whereas it was not inhibitory against Escherichia coli, Proteus vulgaris and various fungi. Confocal microscopy showed that beta-glycyrrhetinic acid was located within the bacteria but had not caused membrane disruption. It then inhibited synthesis of DNA, RNA and protein.
引用
收藏
页码：1899 / 1902
页数：4
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