Phosphoinositide 3-kinase signaling in the vertebrate retina

被引：31

作者：

Rajala, Raju V. S. ^{[1
,2
,3
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机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Dept Ophthalmol, Oklahoma City, OK 73104 USA

[2] Univ Oklahoma, Hlth Sci Ctr, Dept Cell Biol, Oklahoma City, OK 73104 USA

[3] Univ Oklahoma, Hlth Sci Ctr, Dean A McGee Eye Inst, Oklahoma City, OK 73104 USA

来源：

JOURNAL OF LIPID RESEARCH | 2010年 / 51卷 / 01期

基金：

美国国家卫生研究院;

关键词：

ROD OUTER SEGMENTS; PROTEIN-KINASE-C; P70; S6; KINASE; INCREASED INSULIN SENSITIVITY; PLECKSTRIN HOMOLOGY DOMAIN; RECEPTOR-BOUND PROTEIN-14; TYROSINE-PHOSPHATASE; 1B; GROWTH-FACTOR-I; PHOSPHODIESTERASE INHIBITORY SUBUNIT; ACTIN CYTOSKELETAL ORGANIZATION;

D O I：

10.1194/jlr.R000232

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The phosphoinositide (PI) cycle, discovered over 50 years ago by Mabel and Lowell Hokin, describes a series of biochemical reactions that occur on the inner leaflet of the plasma membrane of cells in response to receptor activation by extracellular stimuli. Studies from our laboratory have shown that the retina and rod outer segments (ROSs) have active PI metabolism. Biochemical studies revealed that the ROSs contain the enzymes necessary for phosphorylation of phosphoinositides. We showed that light stimulates various components of the PI cycle in the vertebrate ROS, including diacylglycerol kinase, PI synthetase, phosphatidylinositol phosphate kinase, phospholipase C, and phosphoinositide 3-kinase (PI3K). This article describes recent studies on the PI3K-generated PI lipid second messengers in the control and regulation of PI-binding proteins in the vertebrate retina.-Rajala, R. V. S. Phosphoinositide 3-kinase signaling in the vertebrate retina. J.Lipid. Res. 2010. 51:4-22.

引用

页码：4 / 22

页数：19

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