Selective single C-F bond arylation of trifluoromethylalkene derivatives

被引：63

作者：

Tang, Luning ^{[1
]}

Liu, Ze-Yao ^{[1
]}

She, Wenzhi ^{[1
]}

Feng, Chao ^{[1
]}

机构：

[1] Nanjing Tech Univ, Inst Adv Synth, Sch Chem & Mol Engn, Nanjing 211816, Jiangsu, Peoples R China

来源：

CHEMICAL SCIENCE | 2019年 / 10卷 / 37期

基金：

中国国家自然科学基金;

关键词：

CATALYZED DIFLUOROALKYLATION; GEM-DIFLUOROALLYLATION; FLUORINE ELIMINATION; BORONIC ACIDS; ACTIVATION; HYDRODEFLUORINATION; ALKYLATION; CLEAVAGE; ALKENES; ARENES;

D O I：

10.1039/c9sc01966a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A strategically novel single C-F bond functionalization of CF3-derived molecules, which shows a prominent advantage for the expedient construction of difluoromethylene-bridged organic scaffolds, is disclosed. The reported protocol consists of S(N)2 ' amination, N-alkylation and palladium-catalyzed allylic substitution reactions, which enables straightforward arylation and alkenylation of vinyltrifluoromethane derivatives. Furthermore, this strategy is characterized by its broad substrate scope with respect to both CF3-alkene and arylboronic acid derivatives.

引用

页码：8701 / 8705

页数：5

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