Selective single C-F bond arylation of trifluoromethylalkene derivatives

被引：63
|
作者：
Tang, Luning [1 ]
Liu, Ze-Yao [1 ]
She, Wenzhi [1 ]
Feng, Chao [1 ]
机构：
[1] Nanjing Tech Univ, Inst Adv Synth, Sch Chem & Mol Engn, Nanjing 211816, Jiangsu, Peoples R China
来源：
CHEMICAL SCIENCE | 2019年 / 10卷 / 37期
基金：
中国国家自然科学基金;
关键词：
CATALYZED DIFLUOROALKYLATION; GEM-DIFLUOROALLYLATION; FLUORINE ELIMINATION; BORONIC ACIDS; ACTIVATION; HYDRODEFLUORINATION; ALKYLATION; CLEAVAGE; ALKENES; ARENES;
D O I：
10.1039/c9sc01966a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A strategically novel single C-F bond functionalization of CF3-derived molecules, which shows a prominent advantage for the expedient construction of difluoromethylene-bridged organic scaffolds, is disclosed. The reported protocol consists of S(N)2 ' amination, N-alkylation and palladium-catalyzed allylic substitution reactions, which enables straightforward arylation and alkenylation of vinyltrifluoromethane derivatives. Furthermore, this strategy is characterized by its broad substrate scope with respect to both CF3-alkene and arylboronic acid derivatives.
引用
收藏
页码：8701 / 8705
页数：5
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