Cancer immunotherapy in special challenging populations: recommendations of the Advisory Committee of Spanish Melanoma Group (GEM)

被引:13
|
作者
Gonzalez-Cao, Maria [1 ]
Puertolas, Teresa [2 ]
Riveiro, Mar [3 ]
Munoz-Couselo, Eva [4 ]
Ortiz, Carolina [4 ]
Paredes, Roger [5 ,6 ]
Podzamczer, Daniel [7 ]
Luis Manzano, Jose [8 ]
Molto, Jose [5 ,6 ]
Revollo, Boris [5 ,6 ]
Carrera, Cristina [9 ]
Mateu, Lourdes [5 ,6 ]
Fancelli, Sara [1 ,10 ]
Espinosa, Enrique [11 ]
Clotet, Bonaventura [5 ,6 ]
Martinez-Picado, Javier [5 ,12 ]
Cerezuela, Pablo [13 ]
Soria, Ainara [14 ]
Marquez, Ivan [15 ]
Mandala, Mario [16 ]
Berrocal, Alfonso [17 ]
机构
[1] Dexeus Univ Hosp, Inst Oncol Dr Rosell, Translat Canc Res Unit, Barcelona, Spain
[2] Hosp Univ Miguel Servet, Oncol Dept, Zaragoza, Aragon, Spain
[3] Vall dHebron Hosp Univ, Dept Internal Med, Liver Unit, Barcelona, Spain
[4] Vall dHebron Hosp Univ, Oncol Dept, Barcelona, Catalunya, Spain
[5] IrsiCaixa AIDS Res Inst, Badalona, Catalunya, Spain
[6] Hosp Badalona Germans Trias & Pujol, Dept Infect Dis, Badalona, Catalunya, Spain
[7] Hosp Univ Bellvitge, Dept Infect Dis, Lhospitalet De Llobregat, Catalunya, Spain
[8] Hosp Badalona Germans Trias & Pujol, Onol Dept, Badalona, Spain
[9] Hosp Clin Barcelona, Dermatol Dept, Melanoma Grp IDIBAPS, Barcelona, Catalunya, Spain
[10] Azienda Osped Careggi, Oncol Dept, Florence, Toscana, Italy
[11] Hosp Univ La Paz, Oncol Dept, Madrid, Spain
[12] Catalan Inst Res & Adv Studies, Catalan Inst Res & Adv Studies ICREA, Barcelona, Catalunya, Spain
[13] Hosp Virgen Arrixaca, Oncol Dept, Murcia, Spain
[14] Hosp Ramon & Cajal, Oncol Dept, Madrid, Spain
[15] Hosp Gen Univ Gregorio Maranon, Oncol Dept, Madrid, Spain
[16] ASST Papa Giovanni XXIII, Oncol Dept, Bergamo, Italy
[17] Consorci Hosp Gen Univ Valencia, Oncol Dept, Valencia, Comunitat Valen, Spain
关键词
immunotherapy; IMMUNE CHECKPOINT INHIBITORS; HEPATITIS-B REACTIVATION; TUBERCULOSIS; NIVOLUMAB; THERAPY; HIV; INFECTION; REJECTION; DISEASE; SAFETY;
D O I
10.1136/jitc-2020-001664
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Cancer immunotherapy based on the use of antibodies targeting the so-called checkpoint inhibitors, such as programmed cell death-1 receptor, its ligand, or CTLA-4, has shown durable clinical benefit and survival improvement in melanoma and other tumors. However, there are some special situations that could be a challenge for clinical management. Persons with chronic infections, such as HIV-1 or viral hepatitis, latent tuberculosis, or a history of solid organ transplantation, could be candidates for cancer immunotherapy, but their management requires a multidisciplinary approach. The Spanish Melanoma Group (GEM) panel in collaboration with experts in virology and immunology from different centers in Spain reviewed the literature and developed evidence-based guidelines for cancer immunotherapy management in patients with chronic infections and immunosuppression. These are the first clinical guidelines for cancer immunotherapy treatment in special challenging populations. Cancer immunotherapy in chronically infected or immunosuppressed patients is feasible but needs a multidisciplinary approach in order to decrease the risk of complications related to the coexistent comorbidities.
引用
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页数:9
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