DOCKING OF TYROSINASE CICLOARTANE INHIBITORS

被引：0

作者：

Gutierrez, Pablo A. ^{[1
]}

Rojano, Benjamin A. ^{[1
]}

机构：

[1] Univ Nacl Colombia Medellin, Grp Prod Nat & Alimentos, Lab Ciencia Alimentos, Fac Ciencias, Medellin 3840, Colombia

来源：

VITAE-REVISTA DE LA FACULTAD DE QUIMICA FARMACEUTICA | 2009年 / 16卷 / 02期

关键词：

docking; tyrosinase; cicloartane; inhibitor; ANTIINFLAMMATORY ACTIVITY; CRYSTAL-STRUCTURE; FORCE-FIELD; MODELS; CYCLOARTANE;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Berenjenol (21:24-epoxy-24-methyl-cicloartane) isolated from leaves of Oxandra cf xylopioides (Annonaceae), and its synthetic derivatives Berenjenol-3-acetate and 3-Oxoberenjenol are tyrosinase inhibitors (EC 1.14.18.1). These compounds are triterpenoids type cycloartanes, whose structure-activity relationship has been studied on similar compounds. However, the mechanism of inhibition of these molecules is not well understood. This paper present the results of a docking study between Berenjenol and its derivatives on tyrosinase enzyme that provides a rational framework for understanding the activity of these compounds. According to this work, Berenjenol acts as a competitive inhibitor of tyrosinase through interactions with Ile42, Met43 Arg55, Trp184, Asn191, His194, Val195, Ala202, Met201 and Thr203.

引用

页码：245 / 251

页数：7

共 50 条

[31] Prenylated flavonoids as tyrosinase inhibitors
Lee, NK
Son, KH
Chang, HW
Kang, SS
Park, H
Heo, MY
Kim, HP
ARCHIVES OF PHARMACAL RESEARCH, 2004, 27 (11) : 1132 - 1135
[32] Thermodynamic, kinetic and docking studies of some unsaturated fatty acids-quercetin derivatives as inhibitors of mushroom tyrosinase
Vaezi, Morteza
Behbehani, G. Rezaei
Farasat, Alireza
Gheibi, Nematollah
AIMS BIOPHYSICS, 2020, 7 (04): : 393 - 410
[33] Inhibitors of catalase and tyrosinase.
Baur, E
HELVETICA CHIMICA ACTA, 1939, 22 : 810 - 818
[34] Dialkylphosphorylhydrazones as Potent Tyrosinase Inhibitors
Caixeiro, Janaina M. R.
Goncalves, Vinicius T.
de Oliveira, Marcia C. C.
Sant'Anna, Carlos M. R.
Rumjanek, Victor M.
DaCosta, Joao B. N.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 2012, 23 (05) : 804 - 809
[35] Tyrosinase inhibitors from cumin
Kubo, I
Kinst-Hori, I
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1998, 46 (12) : 5338 - 5341
[36] Thiosemicarbazones as inhibitors of tyrosinase enzyme
Soares, Mariana A.
Almeida, Mariana A.
Marins-Goulart, Carla
Chaves, Otavio A.
Echevarria, Aurea
de Oliveira, Marcia C. C.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 27 (15) : 3546 - 3550
[37] Prenylated flavonoids as tyrosinase inhibitors
Nan Kyoung Lee
Kun Ho Son
Hyeun Wook Chang
Sam Sik Kang
Haeil Park
Moon Young Heo
Hyun Pyo Kim
Archives of Pharmacal Research, 2004, 27 : 1132 - 1135
[38] Thiazol-4(5H)-one analogs as potent tyrosinase inhibitors: Synthesis, tyrosinase inhibition, antimelanogenic effect, antioxidant activity, and in silico docking simulation
Park, Yu Jung
Jung, Hee Jin
Kim, Hye Jin
Park, Hye Soo
Lee, Jieun
Yoon, Dahye
Kang, Min Kyung
Kim, Ga Young
Ullah, Sultan
Kang, Dongwan
Park, Yujin
Chun, Pusoon
Chung, Hae Young
Moon, Hyung Ryong
BIOORGANIC & MEDICINAL CHEMISTRY, 2024, 98
[39] The effect of red betel (Piper crocatum) water fraction as tyrosinase inhibitors: In vitro, molecular docking, and molecular dynamics studies
Safithri, Mega
Andrianto, Dimas
Arda, Adzani Gaisani
Syaifie, Putri Hawa
Kaswati, Nofa Mardia Ningsih
Mardliyati, Etik
Ramadhan, Donny
Jauhar, Muhammad Miftah
Nugroho, Dwi Wahyu
Septaningsih, Dewi Anggraini
Melati, Leni Tria
Hudayanti, Martini
Sarah, Eliwati
Irsal, Riyan Alifibi Putera
Rochman, Nurul Taufiqu
JOURNAL OF KING SAUD UNIVERSITY SCIENCE, 2023, 35 (10)
[40] Benzylidine-N-phenylhydrazine-1-carboxamide Derivatives as Tyrosinase Inhibitors: Design, Preparation, Molecular Docking, and Biological Activity
Hamedifar, Halleh
Karimian, Somaye
Kabiri, Maryam
Bagheri, Azam
Zarei, Mina
Moazzam, Ali
Mahdavi, Mohammad
Sepehri, Nima
Khoshneviszadeh, Mehdi
CHEMISTRYSELECT, 2023, 8 (39):

← 1 2 3 4 5 →