Facile synthesis of (2S,1'S,2'S)-2-(carboxycyclopropyl)glycine, an isotype-selective agonist of metabotropic glutamate receptors

被引：29
|
作者：
Ma, DW
Ma, ZC
机构：
[1] Stt. Key Lab. Bio-Organ. Nat. P., Shanghai Inst. of Organic Chemistry, Chinese Academy of Sciences, 345 Fenglin Lu
来源：
TETRAHEDRON LETTERS | 1997年 / 38卷 / 43期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1016/S0040-4039(97)10037-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
(2S,1'S,2'S)-2-(Carboxycyclopropyl)glycine (L-CCG-I) was synthesized in 12 steps and 14% overall yield by using Sharpless's asymmetric dihydroxylation reaction and stereochemically controlled cyclopropanation as key steps. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码：7599 / 7602
页数：4
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