iso-α-Cyclopiazonic acid, a new natural product isolated from the marine-derived fungus Aspergillus flavus C-F-3

被引：43
|
作者：
Lin, Ai-Qun [1 ]
Du, Lin
Fang, Yu-Chun
Wang, Fa-Zuo
Zhu, Tian-Jiao
Gu, Qian-Qun
Zhu, Wei-Ming
机构：
[1] Ocean Univ China, Key Lab Marine Drugs, Chinese Minist Educ, Qingdao 266003, Peoples R China
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2009年 / 45卷 / 05期
关键词：
Aspergillus flavus; cyclopiazonic acid; cytotoxic activity; SARCOPLASMIC-RETICULUM; BIOSYNTHESIS; CELLS; ASSAY;
D O I：
10.1007/s10600-009-9433-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new natural product, iso-alpha-cyclopiazonic acid (1), together with its isomer alpha-cyclopiazonic acid (2); three mycotoxins: aflatoxin B-1 (AFB(1)) (3), aflatoxin Q(1) (AFQ(1)) (4), and O-methylsterigmatocystin (OMST) (5); two diketopiperazine alkaloids: ditryptophenaline (6) and 3-[(1H-indol-3-yl)methyl]-6-benzylpiperazine-2,5-dione (7), were isolated from the marine-derived fungus Aspergillus flavus. Their structures were determined by analysis of spectroscopic data. The cytotoxicities of compounds 1 and 2 were studied using HL-60, MOLT-4, A-549, and BEL-7402 cell lines.
引用
收藏
页码：677 / 680
页数：4
相关论文
共 50 条
  • [1] iso-α-Cyclopiazonic acid, a new natural product isolated from the marine-derived fungus Aspergillus flavus C-F-3
    Ai-Qun Lin
    Lin Du
    Yu-Chun Fang
    Fa-Zuo Wang
    Tian-Jiao Zhu
    Qian-Qun Gu
    Wei-Ming Zhu
    [J]. Chemistry of Natural Compounds, 2009, 45 : 677 - 680
  • [2] Asperorydines N-P, three new cyclopiazonic acid alkaloids from the marine-derived fungus Aspergillus flavus SCSIO F025
    Xiang, Yao
    Zeng, Qi
    Mai, Zhi-Mao
    Chen, Yu-Chan
    Shi, Xue-Feng
    Chen, Xia-Yu
    Zhong, Wei-Mao
    Wei, Xiao-Yi
    Zhang, Wei-Min
    Zhang, Si
    Wang, Fa-Zuo
    [J]. FITOTERAPIA, 2021, 150
  • [3] New Oxygenated Steroid from the Marine-Derived Fungus Aspergillus flavus
    Yang, Meng-Yue
    Yang, Jian-Kun
    Yang, Jin-Kai
    Hu, Lian-Dong
    Zhu, Hua-Jie
    Cao, Fei
    [J]. NATURAL PRODUCT COMMUNICATIONS, 2018, 13 (08) : 949 - 951
  • [4] Antimicrobial aflatoxins from the marine-derived fungus Aspergillus flavus 092008
    Hui Wang
    Zhenyu Lu
    Hai-Jun Qu
    Peipei Liu
    Chengdu Miao
    Tonghan Zhu
    Jing Li
    Kui Hong
    Weiming Zhu
    [J]. Archives of Pharmacal Research, 2012, 35 : 1387 - 1392
  • [5] Antimicrobial aflatoxins from the marine-derived fungus Aspergillus flavus 092008
    Wang, Hui
    Lu, Zhenyu
    Qu, Hai-Jun
    Liu, Peipei
    Miao, Chengdu
    Zhu, Tonghan
    Li, Jing
    Hong, Kui
    Zhu, Weiming
    [J]. ARCHIVES OF PHARMACAL RESEARCH, 2012, 35 (08) : 1387 - 1392
  • [6] Two new 5-hydroxy-2-pyrone derivatives isolated from a marine-derived fungus Aspergillus flavus
    Lin, Aiqun
    Lu, Xiaoming
    Fang, Yuchun
    Zhu, Tianjiao
    Gu, Qianqun
    Zhu, Weiming
    [J]. JOURNAL OF ANTIBIOTICS, 2008, 61 (04): : 245 - 249
  • [7] Two New 5-Hydroxy-2-pyrone Derivatives Isolated from a Marine-derived Fungus Aspergillus flavus
    Aiqun Lin
    Xiaoming Lu
    Yuchun Fang
    Tianjiao Zhu
    Qianqun Gu
    Weiming Zhu
    [J]. The Journal of Antibiotics, 2008, 61 : 245 - 249
  • [8] Flavusides A and B, Antibacterial Cerebrosides from the Marine-Derived Fungus Aspergillus flavus
    Yang, Guohua
    Sandjo, Louis
    Yun, Keumja
    Leutou, Alain Simplice
    Kim, Gun-Do
    Choi, Hong Dae
    Kang, Jung Sook
    Hong, Jongki
    Son, Byeng Wha
    [J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 2011, 59 (09) : 1174 - 1177
  • [9] A new diphenolic metabolite isolated from the marine-derived fungus Aspergillus niger 102
    Zhang, Pan-Pan
    Song, Shuang
    Lang, Jia-Jia
    Jia, Chun-Xiu
    Yan, Su-Jun
    Liu, Lan
    Chen, Sen-Hua
    Li, Jing
    [J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2019, 21 (08) : 813 - 819
  • [10] Aspermytin A:: a new neurotrophic polyketide isolated from a marine-derived fungus of the genus Aspergillus
    Tsukamoto, S
    Miura, S
    Yamashita, Y
    Ohta, T
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (02) : 417 - 420
12345