Uninformed consent in nutrigenomic research

被引：3

作者：

Janssens, A. Cecile J. W. ^{[1
,2
]}

Bunnik, Eline M. ^{[3
]}

Burke, Wylie ^{[4
]}

Schermer, Maartje H. N. ^{[3
]}

机构：

[1] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, 1518 Clifton Rd NE, Atlanta, GA 30322 USA

[2] Vrije Univ Amsterdam, Med Ctr, Sect Community Genet, Dept Clin Genet,EMGO Inst Hlth & Care Res, Amsterdam, Netherlands

[3] Erasmus MC, Univ Med Ctr Rotterdam, Dept Med Eth & Philosophy Med, Rotterdam, Netherlands

[4] Univ Washington, Dept Bioeth & Humanities, Seattle, WA 98195 USA

来源：

EUROPEAN JOURNAL OF HUMAN GENETICS | 2017年 / 25卷 / 07期

关键词：

RANDOMIZED CONTROLLED-TRIAL; PERSONALIZED NUTRITION; GENOTYPE; FOOD4ME; DISEASE;

D O I：

10.1038/ejhg.2017.63

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genetic testing for personalizing diet and wellness programs is performed without extensive counseling that informs about the potential implications of knowing one's genotype status. Genetic counseling seems redundant for genes that impact the effect of diet on biomarkers such as cholesterol and blood pressure, but the same genes may have pleiotropic effects that cannot be ignored. A well-known example is the APOE gene, which is implicated in cholesterol regulation and is a major risk factor for Alzheimer's disease. Not fully informing participants about the major pleiotropic effects of genes has ethical implications and invalidates informed consent.

引用

页码：789 / 790

页数：2

共 50 条

[31] Uninformed refusals: objections to enrolment in clinical trials conducted under an Exception from Informed Consent for emergency research
Vorholt, Victoria
Dickert, Neal W.
[J]. JOURNAL OF MEDICAL ETHICS, 2019, 45 (01) : 18 - 21
[32] Informed consent and uninformed clinical practice: Dissociation, hypnosis and false memories
Lynn, SJ
[J]. AMERICAN JOURNAL OF CLINICAL HYPNOSIS, 2001, 43 (3-4) : 311 - 321
[33] Informed Consent-Uninformed Participants: Shortcomings of Online Social Science Consent Forms and Recommendations for Improvement
Perrault, Evan K.
Nazione, Samantha A.
[J]. JOURNAL OF EMPIRICAL RESEARCH ON HUMAN RESEARCH ETHICS, 2016, 11 (03) : 274 - 280
[34] "Uninformed" Consent: Patient Recollection From Surgical Consent in Hand Surgery-A Quality Improvement Initiative
Yu, Monica
von Schroeder, Herbert P.
[J]. HAND-AMERICAN ASSOCIATION FOR HAND SURGERY, 2021, 16 (04): : 528 - 534
[35] Informing the Uninformed Optimizing the Consent Message Using a Fractional Factorial Design
Tait, Alan R.
Voepel-Lewis, Terri
Nair, Vijayan N.
Narisetty, Naveen N.
Fagerlin, Angela
[J]. JAMA PEDIATRICS, 2013, 167 (07) : 640 - 646
[36] Informed versus uninformed consent for prostate surgery: The value of electronic consents
Hanno, Philip M.
[J]. JOURNAL OF UROLOGY, 2006, 176 (02): : 699 - 699
[37] Being uninformed on informed consent: A pilot survey of medical education faculty
Mavis B.E.
Henry R.C.
[J]. BMC Medical Education, 5 (1)
[38] An integrated Diet Monitoring Solution for nutrigenomic research
Conti, Costanza
Rossi, Elena
Marceglia, Sara
Tauro, Vittorio
Rizzi, Federica
Lazzaroni, Monica
Barlassina, Cristina
Soldati, Laura
Cusi, Daniele
[J]. DIGITAL HEALTHCARE EMPOWERING EUROPEANS, 2015, 210 : 632 - 636
[39] A RESEARCH NOTE ON TECHNIQUES FOR CONTROLLING UNINFORMED RESPONSES
CAGLEY, JW
SCHNEIDER, KC
JOHNSON, JC
[J]. JOURNAL OF THE MARKET RESEARCH SOCIETY, 1988, 30 (04): : 483 - 487
[40] UNINFORMED RESPONSE ERROR IN SURVEY-RESEARCH
HAWKINS, D
CONEY, KA
[J]. JOURNAL OF MARKETING RESEARCH, 1981, 18 (03) : 370 - 374

← 1 2 3 4 5 →