RuHCl(CO)(PPh3)3-catalyzed reductive dimerization of α,β-unsaturated aldehydes leading to α-hydroxymethyl ketones

被引：28

作者：

Doi, Takashi ^{[1
]}

Fukuyama, Takahide ^{[1
]}

Minamino, Satoshi ^{[1
]}

Ryu, Ilhyong ^{[1
]}

机构：

[1] Osaka Prefecture Univ, Dept Chem, Grad Sch Sci, Sakai, Osaka 5998531, Japan

来源：

SYNLETT | 2006年 / 18期

关键词：

ruthenium enolates; aldol reaction; alpha-hydroxymethyl ketones; alpha; beta-unsaturated aldehydes; transfer hydrogenation;

D O I：

10.1055/s-2006-951518

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reductive dimerization alpha,beta-unsaturated aldehydes to give saturated ketones was achieved using RuHCl(CO)(PPh3)(3) as a catalyst in the presence of secondary alcohols as hydrogen source. The reaction is likely to proceed via the hydroruthenation of alpha,beta-unsaturated aldehydes followed by atdol reaction of the resultant ruthenium enolates with alpha,beta-unsaturated aldehydes to give unsaturated a-hydroxymethyl ketones, which undergo transfer hydrogenation to give alpha-hydroxymethyl ketones.

引用

页码：3013 / 3016

页数：4

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