Hypervalent iodine mediated synthesis of imidazo[1,2-a]pyridine ethers: consecutive methylene linkage and insertion of ethylene glycol

被引：2

作者：

Kumar, Rahul ^{[1
]}

Rawat, Deepa ^{[1
]}

Semwal, Rashmi ^{[1
]}

Badhani, Gaurav ^{[1
]}

Adimurthy, Subbarayappa ^{[1
]}

机构：

[1] Cent Salt & Marine Chem Res Inst, CSIR, Acad Sci & Innovat Res Ghaziabad, GB Marg, Bhavnagar 364002, Gujarat, India

来源：

NEW JOURNAL OF CHEMISTRY | 2021年 / 45卷 / 17期

关键词：

Ethers - Ethylene glycol - Iodine - Ethylene - Organic solvents - Polyols - Synthesis (chemical);

D O I：

10.1039/d1nj00657f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hypervalent iodine mediated selective synthesis of imidazo[1,2-a]pyridine ethers using ethylene glycol as a methoxy ethanol source as well as solvent under metal-free conditions is described. The method is also applicable to other fused heterocycles such as benzo[d]imidazo[2,1-b]thiazoles, 2-(thiophen-2-yl)benzo[d]imidazo [2,1-b]thiazole and indazole. Control experiments suggest that, when the C-3 position of imidazo[1,2-a]pyridine is blocked, the reaction does not take place at any other position showing the regioselectivity of the present protocol.

引用

页码：7491 / 7495

页数：5

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