Synthesis of imidazo[1,2-a] pyridine derivatives as antiviral agents

被引：0
|
作者：
Mavel, S
Renou, JL
Galtier, C
Snoeck, R
Andrei, G
Balzarini, J
De Clercq, E
Gueiffier, A
机构：
[1] Fac Pharm, Chim Therapeut Lab, F-37200 Tours, France
[2] Katholieke Univ Leuven, Rega Inst Med Res, Louvain, Belgium
来源：
ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH | 2001年 / 51卷 / 04期
关键词：
antiviral drugs; imidazo[1,2-a]pyridines, molecular modeling; quantitative structure-activity studies;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis and antiviral activity of original dibromoimidazo[1,2-a]pyridines bearing a thioether side chain are reported. Molecular modeling was used to identify biophoric structural patterns that are common to 16 compounds. Structure-activity relationship (SAR) studies identified hydrophobicity (logP) as the most important factor for activity. From these SAR studies, the antiviral activity could be predicted.
引用
收藏
页码：304 / 309
页数：6
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