Origin, Organization, Dynamics, and Function of Actin and Actomyosin Networks at the T Cell Immunological Synapse

被引:52
|
作者
Hammer, John A. [1 ]
Wang, Jia C. [1 ]
Saeed, Mezida [1 ]
Pedrosa, Antonio T. [1 ]
机构
[1] NHLBI, Cell Biol & Physiol Ctr, NIH, Bethesda, MD 20892 USA
关键词
T cell; actin; myosin; immunological synapse; lytic granule; formin; ALDRICH-SYNDROME PROTEIN; LYTIC GRANULE SECRETION; F-ACTIN; FAMILY PROTEINS; RECEPTOR MICROCLUSTERS; RETROGRADE FLOW; ADAPTER PROTEIN; ARP2/3; COMPLEX; ACTIVATION; CYTOSKELETON;
D O I
10.1146/annurev-immunol-042718-041341
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The engagement of a T cell with an antigen-presenting cell (APC) or activating surface results in the formation within the T cell of several distinct actin and actomyosin networks. These networks reside largely within a narrow zone immediately under the T cell's plasma membrane at its site of contact with the APC or activating surface, i.e., at the immunological synapse. Here we review the origin, organization, dynamics, and function of these synapse-associated actin and actomyosin networks. Importantly, recent insights into the nature of these actin-based cytoskeletal structures were made possible in several cases by advances in light microscopy.
引用
收藏
页码:201 / 224
页数:24
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