Origin, Organization, Dynamics, and Function of Actin and Actomyosin Networks at the T Cell Immunological Synapse

被引:52
|
作者
Hammer, John A. [1 ]
Wang, Jia C. [1 ]
Saeed, Mezida [1 ]
Pedrosa, Antonio T. [1 ]
机构
[1] NHLBI, Cell Biol & Physiol Ctr, NIH, Bethesda, MD 20892 USA
关键词
T cell; actin; myosin; immunological synapse; lytic granule; formin; ALDRICH-SYNDROME PROTEIN; LYTIC GRANULE SECRETION; F-ACTIN; FAMILY PROTEINS; RECEPTOR MICROCLUSTERS; RETROGRADE FLOW; ADAPTER PROTEIN; ARP2/3; COMPLEX; ACTIVATION; CYTOSKELETON;
D O I
10.1146/annurev-immunol-042718-041341
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The engagement of a T cell with an antigen-presenting cell (APC) or activating surface results in the formation within the T cell of several distinct actin and actomyosin networks. These networks reside largely within a narrow zone immediately under the T cell's plasma membrane at its site of contact with the APC or activating surface, i.e., at the immunological synapse. Here we review the origin, organization, dynamics, and function of these synapse-associated actin and actomyosin networks. Importantly, recent insights into the nature of these actin-based cytoskeletal structures were made possible in several cases by advances in light microscopy.
引用
收藏
页码:201 / 224
页数:24
相关论文
共 50 条
  • [1] Organization and dynamics of cell signaling in the immunological synapse
    Yu, Yan
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 245
  • [2] Actin dynamics at the immunological synapse
    Gordon-Alonso, Monica
    Veiga, Esteban
    Sanchez-Madrid, Francisco
    [J]. CELL HEALTH AND CYTOSKELETON, 2010, 2 : 33 - 47
  • [3] Actin retrograde flow and actomyosin II arc contraction drive receptor cluster dynamics at the immunological synapse in Jurkat T cells
    Yi, Jason
    Wu, Xufeng S.
    Crites, Travis
    Hammer, John A., III
    [J]. MOLECULAR BIOLOGY OF THE CELL, 2012, 23 (05) : 834 - 852
  • [4] Morphological Definition of Actin Architecture at the T Cell Immunological Synapse
    Sudha Kumari
    Darrell Irvine
    [J]. Journal of the Indian Institute of Science, 2021, 101 : 47 - 50
  • [5] Morphological Definition of Actin Architecture at the T Cell Immunological Synapse
    Kumari, Sudha
    Irvine, Darrell
    [J]. JOURNAL OF THE INDIAN INSTITUTE OF SCIENCE, 2021, 101 (01) : 47 - 50
  • [6] The role of actomyosin and the microtubular network in both the immunological synapse and T cell activation
    Rey, Mercedes
    Sanchez-Madrid, Francisco
    Valenzuela-Fernandez, Agustin
    [J]. FRONTIERS IN BIOSCIENCE-LANDMARK, 2007, 12 : 437 - 447
  • [7] The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling
    Dustin, ML
    Cooper, JA
    [J]. NATURE IMMUNOLOGY, 2000, 1 (01) : 23 - 29
  • [8] The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling
    Michael L. Dustin
    John A. Cooper
    [J]. Nature Immunology, 2000, 1 : 23 - 29
  • [9] Nuclear Envelope Lamin-A Couples Actin Dynamics with Immunological Synapse Architecture and T Cell Activation
    Gonzalez-Granado, Jose M.
    Silvestre-Roig, Carlos
    Rocha-Perugini, Vera
    Trigueros-Motos, Laia
    Cibrian, Danay
    Morlino, Giulia
    Blanco-Berrocal, Marta
    Osorio, Fernando G.
    Freije, Jose M. P.
    Lopez-Otin, Carlos
    Sanchez-Madrid, Francisco
    Andres, Vicente
    [J]. SCIENCE SIGNALING, 2014, 7 (322)
  • [10] Multiple actin networks coordinate mechanotransduction at the immunological synapse
    Blumenthal, Daniel
    Burkhardt, Janis K.
    [J]. JOURNAL OF CELL BIOLOGY, 2020, 219 (02):