Harnessing affinity-based protein profiling to reveal a novel target of nintedanib

被引：2
|
作者：
Chen, Xiong [1 ]
Li, Menglin [1 ]
Li, Manru [1 ]
Wang, Dongmei [1 ]
Zhang, Jinlan [1 ]
机构：
[1] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2021年 / 57卷 / 25期
关键词：
D O I：
10.1039/d1cc00354b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Nintedanib (BIBF1120), a triple angiokinase inhibitor, was first approved for idiopathic pulmonary fibrosis (IPF) therapy and is also efficacious for lung carcinoma, and interstitial lung diseases, far beyond its inhibition of VEGFR/PDGFR/FGFR. We identified tripeptidyl-peptidase 1 (TPP1) as one of the direct targets of nintedanib employing the affinity-based protein profiling (AfBPP) technique. This may be a new mechanism for nintedanib's role different from tyrosine kinase inhibition.
引用
收藏
页码：3139 / 3142
页数：4
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