Harnessing affinity-based protein profiling to reveal a novel target of nintedanib

被引：2

作者：

Chen, Xiong ^{[1
]}

Li, Menglin ^{[1
]}

Li, Manru ^{[1
]}

Wang, Dongmei ^{[1
]}

Zhang, Jinlan ^{[1
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2021年 / 57卷 / 25期

关键词：

D O I：

10.1039/d1cc00354b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nintedanib (BIBF1120), a triple angiokinase inhibitor, was first approved for idiopathic pulmonary fibrosis (IPF) therapy and is also efficacious for lung carcinoma, and interstitial lung diseases, far beyond its inhibition of VEGFR/PDGFR/FGFR. We identified tripeptidyl-peptidase 1 (TPP1) as one of the direct targets of nintedanib employing the affinity-based protein profiling (AfBPP) technique. This may be a new mechanism for nintedanib's role different from tyrosine kinase inhibition.

引用

页码：3139 / 3142

页数：4

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