Crosstalk Between Mucosal Inflammation and Bone Metabolism in Chronic Rhinosinusitis

被引：18

作者：

Khalmuratova, Roza ^{[1
]}

Shin, Hyun-Woo ^{[1
,2
,3
,4
,5
]}

机构：

[1] Seoul Natl Univ, Coll Med, Dept Pharmacol, Obstruct Upper Airway Res OUaR Lab, Seoul, South Korea

[2] Seoul Natl Univ, Coll Med, Dept Biomed Sci, Seoul, South Korea

[3] Seoul Natl Univ, Coll Med, Ischem Hypox Dis Inst, Seoul, South Korea

[4] Seoul Natl Univ, Coll Med, Canc Res Inst, Seoul, South Korea

[5] Seoul Natl Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, 103 Daehak Ro, Seoul 03080, South Korea

来源：

CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY | 2021年 / 14卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Osteitis; Chronic Rhinosinusitis; Inflammation; Osteoblasts; Osteoclasts; Cytokine; EOSINOPHILIC CHRONIC RHINOSINUSITIS; P-GLYCOPROTEIN; NASAL POLYPS; GENE-EXPRESSION; COMPUTED-TOMOGRAPHY; TISSUE EOSINOPHILIA; CHRONIC SINUSITIS; ENTEROTOXIN-B; CT ANALYSIS; OSTEITIS;

D O I：

10.21053/ceo.2020.00416

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Chronic rhinosinusitis (CRS) is a multifactorial and highly heterogeneous upper airway disease that affects approximately 12% of the general population. There is increasing evidence supporting the impact of osteitis on the pathophysiology of CRS. Osteitis is frequently observed in patients with CRS, and is associated with severe sinonasal inflammation and recalcitrant cases. The overlying inflammatory sinonasal mucosa plays a critical role in the initiation of osteitis; however, the underlying molecular mechanisms and functional significance remain unclear. Increasingly many studies have suggested that immune cells play a crucial role in the bone remodeling process in CRS. The purpose of this review is to summarize the current state of knowledge regarding the specific role of sinonasal inflammation in bone remodeling in CRS patients.

引用

页码：43 / 49

页数：7

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