Calcium dynamics regulating the timing of decision-making in C. elegans

被引：39

作者：

Tanimoto, Yuki ^{[1
]}

Yamazoe-Umemoto, Akiko ^{[1
]}

Fujita, Kosuke ^{[1
,8
]}

Kawazoe, Yuya ^{[1
]}

Miyanishi, Yosuke ^{[1
]}

Yamazaki, Shuhei J. ^{[1
]}

Fei, Xianfeng ^{[2
]}

Busch, Karl Emanuel ^{[3
]}

Gengyo-Ando, Keiko ^{[4
]}

Nakai, Junichi ^{[5
]}

Lino, Yuichi ^{[6
]}

Iwasaki, Yuishi ^{[7
]}

Hashimoto, Koichi

Kimura, Koutarou D. ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Sci, Dept Biol Sci, Toyonaka, Osaka, Japan

[2] Tohoku Bunka Gakuen Univ, Fac Sci & Technol, Sendai, Miyagi, Japan

[3] Univ Edinburgh, Ctr Integrat Physiol, Edinburgh, Midlothian, Scotland

[4] Saitama Univ, Grad Shool Sci & Engn Brain & Body Syst Sci Inst, Saitama, Japan

[5] Univ Tokyo, Grad Sch Sci, Dept Biol Sci, Tokyo, Japan

[6] Ibaraki Univ, Dept Intelligent Syst Engn, Hitachi, Ibaraki, Japan

[7] Tohoku Univ, Grad Sch Informat Sci, Sendai, Miyagi, Japan

[8] Tohoku Univ, Grad Sch Med, Dept Ophthalmol, Sendai, Miyagi, Japan

来源：

ELIFE | 2017年 / 6卷

基金：

日本学术振兴会;

关键词：

NEURAL ACTIVITY; IN-VIVO; NEURONS; CHANNEL; DOPAMINE; GENES; INTEGRATION; ADAPTATION; SEROTONIN; RESPONSES;

D O I：

10.7554/eLife.21629

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Brains regulate behavioral responses with distinct timings. Here we investigate the cellular and molecular mechanisms underlying the timing of decision-making during olfactory navigation in Caenorhabditis elegans. We find that, based on subtle changes in odor concentrations, the animals appear to choose the appropriate migratory direction from multiple trials as a form of behavioral decision-making. Through optophysiological, mathematical and genetic analyses of neural activity under virtual odor gradients, we further find that odor concentration information is temporally integrated for a decision by a gradual increase in intracellular calcium concentration ([Ca2+](i)), which occurs via L-type voltage-gated calcium channels in a pair of olfactory neurons. In contrast, for a reflex-like behavioral response, [Ca2+](i) rapidly increases via multiple types of calcium channels in a pair of nociceptive neurons. Thus, the timing of neuronal responses is determined by cell type-dependent involvement of calcium channels, which may serve as a cellular basis for decision-making.

引用

页数：30

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