Role of exosomes in pancreatic cancer

被引：11
|
作者：
Liu, Hao [1 ]
Qiao, Shishi [1 ]
Fan, Xiaoyue [2 ]
Gu, Yufei [1 ]
Zhang, Yingxuan [1 ]
Huang, Shuai [1 ]
机构：
[1] Zhengzhou Univ, Affiliated Hosp 1, Dept Hepatobiliary & Pancreat Surg, 1 Jianshe East Rd, Zhengzhou 450052, Henan, Peoples R China
[2] Zhengzhou Univ, Affiliated Hosp 1, Dept Pathol, Zhengzhou 450052, Henan, Peoples R China
来源：
ONCOLOGY LETTERS | 2021年 / 21卷 / 04期
关键词：
exosomes; pancreatic cancer; proliferation; migration; invasion; mechanisms; TUMOR-ASSOCIATED MACROPHAGE; REGULATORY T-CELLS; INTERCELLULAR-COMMUNICATION; MEDIATED METASTASIS; DENDRITIC CELLS; IN-VITRO; MICRORNAS; DELIVERY; RNA; SERUM;
D O I：
10.3892/ol.2021.12559
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Pancreatic cancer (PC) is a malignant tumour of the human digestive system that has a poor prognosis. Exosomes contain proteins and nucleic acids, and constitute a class of extracellular vesicles defined as membrane-bound nanovesicles of endocytic origin, with a diameter of 40-150 nm. Exosomes are potential diagnostic markers of PC; however, their roles in cancer initiation and progression remain unclear. Previous studies have focused on the molecular mechanisms and functions of exosomes that allow them to accelerate PC cell proliferation, migration and invasion. The present review discusses the interactions between exosomes and the pathophysiology of PC. The potential clinical applications of exosomes are also discussed.
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页数：13
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