SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 1-[4-(1-ADAMANTYL)PHENOXY]-3-AMINO-2-PROPANOL

被引：2
|
作者：
Korotkii, Yu. V. [1 ]
Vrynchanu, N. A. [2 ]
Maksimov, Yu. N. [2 ]
Lozinskii, M. O. [1 ]
机构：
[1] Natl Acad Sci Ukraine, Inst Organ Chem, Kiev, Ukraine
[2] Natl Acad Sci Ukraine, Inst Pharmacol & Toxicol, Kiev, Ukraine
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2009年 / 43卷 / 06期
关键词：
adamantane; aminopropanols; epoxide; antibacterial activity; antifungal activity; VIVO GROWTH-INHIBITION; IN-VITRO; CELLS;
D O I：
10.1007/s11094-009-0299-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Reaction of 1-[4-(1-adamantyl)phenoxy]glycidyl ether with amines leads to the corresponding 1-[4-(1-adamantyl)phenoxy]-3-alkyl(dialkyl) amino-2-propanols. The proposed structures of the synthesized compounds are confirmed by IR and NMR spectroscopy. Substances tested by the serial dilution method exhibited a high level of antimicrobial activity.
引用
收藏
页码：301 / 304
页数：4
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