And Akt-ion! IQGAP1 in control of signaling pathways

被引：15

作者：

Choi, Suyong ^{[1
]}

Anderson, Richard A. ^{[1
]}

机构：

[1] Univ Wisconsin, Sch Med & Publ Hlth, Madison, WI 53706 USA

来源：

EMBO JOURNAL | 2017年 / 36卷 / 08期

关键词：

D O I：

10.15252/embj.201796827

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

ERK signaling and Akt signaling are inversely correlated in some cancers. Yet, the precise molecular mechanism for cross-inhibition remains unclear. In this issue of The EMBO Journal, Pan et al (2017) show that when Akt is on, its phosphorylated cytoplasmic substrate FOXO1 turns off ERK activity by reshaping the Ras-ERK scaffold IQGAP1.

引用

页码：967 / 969

页数：3

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