Chemosensors for the marine toxin saxitoxin

被引：57
|
作者：
Gawley, RE
Pinet, S
Cardona, CM
Datta, PK
Ren, T
Guida, WC
Nydick, J
Leblanc, RM
机构：
[1] Univ Miami, Dept Chem, Coral Gables, FL 33124 USA
[2] Univ Miami, NIEHS, Marine & Freshwater Biomed Sci Ctr, Coral Gables, FL 33124 USA
[3] Eckerd Coll, Dept Chem, Petersburg, FL 33711 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 45期
关键词：
D O I：
10.1021/ja027507p
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Eleven anthracylmethyl crown ethers have been synthesized and evaluated as fluorescence sensors for the marine toxin saxitoxin. Fluorescence enhancement data are consistent with a 1:1 binding complex for all crowns. The binding constants are in the range of 10(4) M-1 in ammonium phosphate buffer (pH 7.1) in 80% ethanol solvent. Selectivity for sensing saxitoxin versus several organic analytes has been demonstrated for the first time. Possible modes of binding are presented, and relevance to saxitoxin monitoring programs are discussed.
引用
收藏
页码：13448 / 13453
页数：6
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