Antimicrobial Evaluation of Mangiferin Analogues

被引：24

作者：

Singh, S. K. ^{[1
]}

Kumar, Y. ^{[2
]}

Kumar, S. Sadish ^{[2
]}

Sharma, V. K. ^{[1
]}

Dua, K. ^{[1
]}

Samad, A. ^{[1
]}

机构：

[1] DJ Coll Pharm, Modinagar 201201, India

[2] ITS Paramed Coll Pharm, Muradnagar 201206, Ghaziabad, India

来源：

INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2009年 / 71卷 / 03期

关键词：

Antifungal; antimicrobial; Mangifera indica; mangiferin; INDICA; COMPONENTS; VIMANG;

D O I：

10.4103/0250-474X.56023

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The naturally occurring xanthone glycoside mangiferin has been isolated by column chromatography from the ethanol extract of stem bark of Mangifera indica. Mangiferin was further converted to 5-(N-phenylaminomethyleno) mangiferin, 5-(N-p-chlorophenylaminomethyleno) mangiferin, 5-(N-2-methylphenylaminomethyleno) mangiferin, 5-(N-p-methoxyphenylaminomethyleno) mangiferin, 5-(N,N-diphenylaminomethyleno) mangiferin, 5-(N-anapthylaminomethyleno) mangiferin and 5-(N-4-methylphenylaminomethyleno) mangiferin. Mangiferin and its analogues were characterized by melting point and R-f value determination and through spectral technique like UV, IR, and NMR spectral analysis. The synthesized compounds were screened for antimicrobial activity.

引用

页码：328 / U106

页数：4

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