Use of pentoxifylline and tocopherol in radiation-induced fibrosis and fibroatrophy

被引：28
|
作者：
Patel, V. [1 ]
McGurk, M. [2 ]
机构：
[1] Guys Dent Hosp, Dept Oral Surg, Floor 23, London SE1 9RT, England
[2] Guys Hosp, Dept Oral & Maxillofacial Surg, Atrium 3,3rd Floor,Bermondsey Wing, London SE1 9RT, England
来源：
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY | 2017年 / 55卷 / 03期
关键词：
Radiation-induced fibrosis; pentoxifylline; tocopherol; TREATMENT COMBINING PENTOXIFYLLINE; CU/ZN SUPEROXIDE-DISMUTASE; INDUCED PULMONARY-FIBROSIS; LONG-TERM TREATMENT; VITAMIN-E; ALPHA-TOCOPHEROL; BREAST-CANCER; CONSERVATION THERAPY; STRIKING REGRESSION; IATROGENIC FIBROSIS;
D O I：
10.1016/j.bjoms.2016.11.323
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
Radiation-induced fibrosis in the head and neck is a well-established pathophysiological process after radiotherapy. Recently pentoxifylline and tocopherol have been proposed as treatments to combat the late complications of radiation-induced fibrosis and a way of dealing with osteoradionecrosis. They both have a long history in the management of radiation-induced fibrosis at other anatomical sites. In this paper we review their use in sites other than the head and neck to illustrate the potential benefit that they offer to our patients. (C) 2016 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：235 / 241
页数：7
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