A practical synthesis of para di- and mono-substituted benzhydrylamines from benzhydrol precursors

被引：0
|
作者：
Laurent, M [1 ]
Marchand-Brynaert, J [1 ]
机构：
[1] Univ Catholique Louvain, Lab Chim Organ Synthese, B-1348 Louvain, Belgium
来源：
SYNTHESIS-STUTTGART | 2000年 / 05期
关键词：
benzhydrylamines; chiral chromatography; (+)-4-chlorobenzhydrylamine; (-)-4-chlorobenzhydrylamine; hydrolyses; deprotection;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of para-substituted benzhydrylamines 6 were obtained by substitution of the corresponding benzhydrol precursors 1 with phenyl carbamate 2 under acidic conditions, followed by basic hydrolysis of the carbamate intermediates 3. One unsymmetrical intermediate 3i has been resolved by preparative chiral chromatography. Subsequent deprotection of the carbamate function led to the recovery of enantiomerically pure (+)- and (-)-4-chlorobenzhydryl amines.
引用
收藏
页码：667 / 672
页数：6
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