Enhanced Protection Against Diarrhea Among Breastfed Infants of Nonsecretor Mothers

被引：5
|
作者：
Muthumuni, Dhasni [1 ,2 ]
Miliku, Kozeta [1 ,2 ]
Wade, Kaitlin H. [3 ,4 ]
Timpson, Nicholas J. [3 ,4 ,5 ]
Azad, Meghan B. [1 ,2 ]
机构：
[1] Univ Manitoba, Dept Pediat & Child Hlth, Winnipeg, MB, Canada
[2] Childrens Hosp Res Inst Manitoba, Manitoba Interdisciplinary Lactat Ctr MILC, Winnipeg, MB, Canada
[3] Univ Bristol, Fac Hlth Sci, Bristol Med Sch, Populat Hlth Sci, Bristol, Avon, England
[4] Univ Bristol, Med Res Council, Integrat Epidemiol Unit, Bristol, Avon, England
[5] Univ Bristol, Avon Longitudinal Study Parents & Children, Bristol, Avon, England
来源：
PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2021年 / 40卷 / 03期
基金：
英国惠康基金;
关键词：
fucosyltransferase-2; secretor status; breast milk; diarrhea; pediatrics;
D O I：
10.1097/INF.0000000000003014
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Diarrhea is a major cause of infant mortality. Being a "nonsecretor" (having an inactive fucosyltransferase-2 gene) protects against diarrhea by inhibiting enteric infections. Breastfeeding also protects against diarrhea; however, the impact of maternal secretor status is unknown. In the ALSPAC cohort (N = 4971), we found that breastfeeding by nonsecretor mothers was especially protective against diarrhea, which could inform new prevention strategies.
引用
收藏
页码：260 / 263
页数：4
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