Enhanced Protection Against Diarrhea Among Breastfed Infants of Nonsecretor Mothers

被引：5

作者：

Muthumuni, Dhasni ^{[1
,2
]}

Miliku, Kozeta ^{[1
,2
]}

Wade, Kaitlin H. ^{[3
,4
]}

Timpson, Nicholas J. ^{[3
,4
,5
]}

Azad, Meghan B. ^{[1
,2
]}

机构：

[1] Univ Manitoba, Dept Pediat & Child Hlth, Winnipeg, MB, Canada

[2] Childrens Hosp Res Inst Manitoba, Manitoba Interdisciplinary Lactat Ctr MILC, Winnipeg, MB, Canada

[3] Univ Bristol, Fac Hlth Sci, Bristol Med Sch, Populat Hlth Sci, Bristol, Avon, England

[4] Univ Bristol, Med Res Council, Integrat Epidemiol Unit, Bristol, Avon, England

[5] Univ Bristol, Avon Longitudinal Study Parents & Children, Bristol, Avon, England

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2021年 / 40卷 / 03期

基金：

英国惠康基金;

关键词：

fucosyltransferase-2; secretor status; breast milk; diarrhea; pediatrics;

D O I：

10.1097/INF.0000000000003014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Diarrhea is a major cause of infant mortality. Being a "nonsecretor" (having an inactive fucosyltransferase-2 gene) protects against diarrhea by inhibiting enteric infections. Breastfeeding also protects against diarrhea; however, the impact of maternal secretor status is unknown. In the ALSPAC cohort (N = 4971), we found that breastfeeding by nonsecretor mothers was especially protective against diarrhea, which could inform new prevention strategies.

引用

页码：260 / 263

页数：4

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