Developmental Changes in Hepatic Antioxidant Capacity Are Age- and Sex-Dependent

被引：13
|
作者：
Miyagi, Shogo J. [1 ]
Brown, Isaac W. [1 ]
Chock, Jessica M-L. [1 ]
Collier, Abby C. [1 ,2 ]
机构：
[1] Univ Hawaii, John A Burns Sch Med, Dept Trop Med Med Microbiol & Pharmacol, Honolulu, HI 96813 USA
[2] Univ Hawaii, John A Burns Sch Med, Inst Biogenesis Res, Honolulu, HI 96813 USA
来源：
JOURNAL OF PHARMACOLOGICAL SCIENCES | 2009年 / 111卷 / 04期
关键词：
oxidative stress; pediatric liver disease; detoxification enzyme; OXIDATIVE STRESS; VITAMIN-E; GLUTATHIONE; TRANSFERASES; DISEASE; LIVER;
D O I：
10.1254/jphs.09223SC
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Developmental inadequacy in hepatic antioxidant defenses may contribute to chemical toxicity and pediatric liver diseases. We measured a comprehensive panel of antioxidants in liver tissue from 27 normal pediatric donors. Glutathione reductase declined with age (P = 0.008, r = -0.54, Spearman) while microsomal glutathione-S-transferase increased (GST, P < 0.001, r = 0.81). Males had significantly lower superoxide dismutase and vitamin E (P < 0.05) and may have lower glutathione reductase (P = 0.06), while females show less cytosolic GST (P = 0.07). Hepatic antioxidants are high in neonates, decline throughout childhood, and then increase in adolescence to adult levels.
引用
收藏
页码：440 / 445
页数：6
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