Decarboxylative C(sp3)-N Cross-Coupling of Diacyl Peroxides with Nitrogen Nucleophiles

被引：26
|
作者：
Tang, Zi-Liang [1 ]
Ouyang, Xuan-Hui [1 ]
Song, Ren-Jie [1 ,2 ]
Li, Jin-Heng [1 ,2 ,3 ]
机构：
[1] Nanchang Hangkong Univ, Key Lab Jiangxi Prov Persistent Pollutants Contro, Nanchang 330063, Jiangxi, Peoples R China
[2] Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China
[3] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
来源：
ORGANIC LETTERS | 2021年 / 23卷 / 03期
关键词：
D O I：
10.1021/acs.orglett.0c04203
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We have disclosed a new radical-mediated decarboxylative C(sp(3))-N cross-coupling of diacyl peroxides with nitrogen nucleophiles. The primary and secondary alkyl radicals derived from corresponding diacyl peroxides were generated by copper catalysis or by merging copper catalysis and photoredox catalysis, respectively. Various N-alkyl nitrogen nucleophiles, including indazoles, triazoles, indoles, purine, carbazole, anilines, and sulfonamide, were provided with a broad substrate scope and good functional group tolerance.
引用
收藏
页码：1000 / 1004
页数：5
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