A mathematical model for the evaluation of amplitude of hemoglobin fluctuations in elderly anemic patients affected by myelodysplastic syndromes: correlation with quality of life and fatigue

被引：27
|
作者：
Caocci, Giovanni
Baccoli, Roberto
Ledda, Antonio
Littera, Roberto
La Nasa, Giorgio
机构：
[1] Ctr Trapianti Midollo Osseo, Unita Operat, I-09126 Cagliari, Italy
[2] Univ Cagliari, Fac Ingn, I-09123 Cagliari, Italy
来源：
LEUKEMIA RESEARCH | 2007年 / 31卷 / 02期
关键词：
hemoglobin fluctuation; anemia; myelodisplasia; quality of life; fatigue;
D O I：
10.1016/j.leukres.2006.05.015
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Therapy with RBC transfusions and rHuEPO for management of anemia in patients with myelodysplastic syndromes causes recurrent fluctuations in hemoglobin levels. The purpose of this study was to elaborate a mathematical model for the interpretation of hemoglobin fluctuations and to correlate the resulting numerical parameter (Variaglobin Index) with quality of life and fatigue. In 32 myelodysplastic patients, lower amplitude of the Variaglobin Index was found significantly correlated with a better quality of life and less fatigue. The mathematical model proposed here makes it easy to monitor anemia in myelodysplastic patients and to adjust therapy accordingly. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：249 / 252
页数：4
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