Effect of cessation of drug misuse on the immune status of HIV-infected injecting drug users

被引：0
|
作者：
Radkowski, M
Werezynska, T
Laskus, T
Kaminska, E
Kuligowski, S
机构：
[1] INST INFECT & PARASIT DIS, WARSAW, POLAND
[2] CTR AIDS DIAG & THERAPY, WARSAW, POLAND
[3] NOWOWIEJSKI HOSP, REG DETOXIFICAT CTR, WARSAW, POLAND
[4] UNIV PITTSBURGH, MED CTR, PITTSBURGH, PA USA
来源：
ADDICTION BIOLOGY | 1997年 / 2卷 / 01期
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effects of cessation of i.v. drug use on CD4 lymphocyte count and serum levels of beta(2)-microglobulin (beta(2)m) and soluble interleukin-2 receptor (sIL-2R) were prospectively investigated in 41 HIV-positive drug users enrolled in a methadone treatment programme. Fifteen HIV-positive matched non-abstainers served as controls. During the follow-up of 12 months the mean CD4 lymphocyte count remained unchanged in the methadone-treated group but fell significantly in controls. beta(2)m and sIL-2R values decreased in abstainers at the beginning of the treatment but rose in non-abstaining group. We conclude that cessation of illicit drug abuse and methadone treatment in HIV-infected injecting drug users may exert a beneficial effect on the immune status.
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页码：95 / 99
页数：5
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