Synthesis of 3,4,5-trisubstituted piperidine via SN2' reaction

被引：4
|
作者：
Li, Fei [1 ]
Wang, Xue [1 ]
Liu, Yue Meng [1 ]
Zhang, Jing [1 ]
Yang, Jun [1 ]
机构：
[1] Shaanxi Normal Univ, Sch Chem & Chem Engn, Key Lab Macromol Sci Shaanxi Prov, Key Lab Minist Educ Med Resources & Nat Pharmaceu, Changan Campus 620,West Changan Ave, Xian 710119, Shaanxi, Peoples R China
来源：
SYNTHETIC COMMUNICATIONS | 2020年 / 50卷 / 01期
基金：
中国国家自然科学基金;
关键词：
3; 4; 5-Trisubstituted piperidine; SN2' reaction; synthesis; PYRROLIDINE;
D O I：
10.1080/00397911.2019.1682612
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
3,4,5-Trisubstituted piperidine-containing compounds displayed a range of biological activities, are potential drug candidates to treatment of Alzheimer's disease, sexual dysfunctions or obesity, heart and kidney insufficiency. However, the inherent difficulty in obtaining a variety of 3,4,5-trisubstituted piperidines has greatly hindered their systematic medicinal chemistry studies for them. In this paper, we disclose an efficient synthesis of racemic and chiral 3,4,5-trisubstituted piperidines via S(N)2' reaction.
引用
收藏
页码：56 / 62
页数：7
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