Inherited cancer syndromes in gynaecology:: what the practitioner needs to know!

被引：0
|
作者：
Kuschel, B
Köchli, OR
Niederacher, D
Müller, H
Beckmann, MW
机构：
[1] Univ Dusseldorf, Frauenklin, D-4000 Dusseldorf, Germany
[2] Univ Basel, Kantonsspital, Frauenklin, CH-4031 Basel, Switzerland
[3] UKBB, Abt Med Genet, Basel, Switzerland
来源：
SCHWEIZERISCHE MEDIZINISCHE WOCHENSCHRIFT | 2000年 / 130卷 / 10期
关键词：
inherited cancer syndromes; genetic testing; gynaecological oncology;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
During the last 5 years progress in molecular genetics has offered the possibility of genetic testing for inherited mutations of cancer-predisposing genes. The exact cellular function and carcinogenic potential of these genes is yet not completely understood. Only in 5-20% of all cancers inherited genetic mutations play an important role in the polygenic and multifactorial nature of the disease. Identification of inherited cancer syndromes, predictive genetic testing, and counselling of women and family members at increased risk is of clinical importance. The debate surrounding presymptomatic diagnostic testing and adequate programmes for early cancer detection, prevention or clinical follow-up continues.
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页码：362 / 375
页数：16
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