Improved Murine Model of Malaria Using Plasmodium falciparum Competent Strains and Non-Myelodepleted NOD-scid IL2Rγnull Mice Engrafted with Human Erythrocytes

被引：151

作者：

Belen Jimenez-Diaz, Maria ^{[1
]}

Mulet, Teresa ^{[1
]}

Viera, Sara ^{[1
]}

Gomez, Vanessa ^{[1
]}

Garuti, Helen ^{[1
]}

Ibanez, Javier ^{[1
]}

Alvarez-Doval, Angela ^{[1
]}

Shultz, Leonard D. ^{[2
]}

Martinez, Antonio ^{[1
]}

Gargallo-Viola, Domingo ^{[1
]}

Angulo-Barturen, Inigo ^{[1
]}

机构：

[1] GlaxoSmithKline Inc, ID CEDD Dis Developing World, Tres Cantos 28760, Spain

[2] Jackson Lab, Bar Harbor, ME 04609 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 10期

关键词：

BIOMEDICAL-RESEARCH; SELECTION;

D O I：

10.1128/AAC.00519-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Murine models of Plasmodium falciparum malaria may become crucial tools in drug discovery. Here we show that non-myelodepleted NOD-scid IL2R gamma(null) mice engrafted with human erythrocytes support an infectious burden up to tenfold higher than that supported by engrafted NOD-scid beta 2microglobulin(null) mice. The new model was validated for drug discovery and was used to assess the therapeutic efficacy of 4-pyridones, selective inhibitors of P. falciparum cytochrome bc(1).

引用

页码：4533 / 4536

页数：4

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