Improved Murine Model of Malaria Using Plasmodium falciparum Competent Strains and Non-Myelodepleted NOD-scid IL2Rγnull Mice Engrafted with Human Erythrocytes

被引：151

作者：

Belen Jimenez-Diaz, Maria ^{[1
]}

Mulet, Teresa ^{[1
]}

Viera, Sara ^{[1
]}

Gomez, Vanessa ^{[1
]}

Garuti, Helen ^{[1
]}

Ibanez, Javier ^{[1
]}

Alvarez-Doval, Angela ^{[1
]}

Shultz, Leonard D. ^{[2
]}

Martinez, Antonio ^{[1
]}

Gargallo-Viola, Domingo ^{[1
]}

Angulo-Barturen, Inigo ^{[1
]}

机构：

[1] GlaxoSmithKline Inc, ID CEDD Dis Developing World, Tres Cantos 28760, Spain

[2] Jackson Lab, Bar Harbor, ME 04609 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 10期

关键词：

BIOMEDICAL-RESEARCH; SELECTION;

D O I：

10.1128/AAC.00519-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Murine models of Plasmodium falciparum malaria may become crucial tools in drug discovery. Here we show that non-myelodepleted NOD-scid IL2R gamma(null) mice engrafted with human erythrocytes support an infectious burden up to tenfold higher than that supported by engrafted NOD-scid beta 2microglobulin(null) mice. The new model was validated for drug discovery and was used to assess the therapeutic efficacy of 4-pyridones, selective inhibitors of P. falciparum cytochrome bc(1).

引用

页码：4533 / 4536

页数：4

共 50 条

[1] A Murine Model of falciparum-Malaria by In Vivo Selection of Competent Strains in Non-Myelodepleted Mice Engrafted with Human Erythrocytes
Angulo-Barturen, Inigo
Belen Jimenez-Diaz, Maria
Mulet, Teresa
Rullas, Joaquin
Herreros, Esperanza
Ferrer, Santiago
Jimenez, Elena
Mendoza, Alfonso
Regadera, Javier
Rosenthal, Philip J.
Bathurst, Ian
Pompliano, David L.
Gomez de las Heras, Federico
Gargallo-Viola, Domingo
PLOS ONE, 2008, 3 (05):
[2] NOD-SCID IL2R-/- MICE ENGRAFTED WITH HUMAN ERYTHROCYTES SUPPORT HIGHER PLASMODIUM FALCIPARUM-PARASITEMIAS THAN NOD-SCID β MICROGLOBULIN-/- ENGRAFTED MICE
Jimenez-Diaz, Belen
Mulet, Teresa
Vieral, Sara
Gomez, Vanesa
Garuti, Helen
Alvarez, Angela
Ibanez, Javier
Shultz, Leonard
Gargallo-Viola, Domingo
Angulo-Barturen, Inigo
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2008, 79 (06): : 173 - 173
[3] Pregnancy-Induced Proliferation of Human β-Cells Engrafted into Immunodeficient NOD-scid IL2rγnull Mice
Jurczyk, Agata
Sharma, Rohit
Yang, Chaoxing
Shultz, Leonard
Greiner, Dale
Alonso, Laura C.
Bortell, Rita
DIABETES, 2017, 66 : A565 - A566
[4] NOD-scid IL2R γnull mice engrafted with human peripheral blood mononuclear cells as a model to test therapeutics targeting human signaling pathways
Maryam Zadeh-Khorasani
Thomas Nolte
Thomas D Mueller
Markos Pechlivanis
Franziska Rueff
Andreas Wollenberg
Gert Fricker
Eckhard Wolf
Matthias Siebeck
Roswitha Gropp
Journal of Translational Medicine, 11
[5] NOD-scid IL2R γnull mice engrafted with human peripheral blood mononuclear cells as a model to test therapeutics targeting human signaling pathways
Zadeh-Khorasani, Maryam
Nolte, Thomas
Mueller, Thomas D.
Pechlivanis, Markos
Rueff, Franziska
Wollenberg, Andreas
Fricker, Gert
Wolf, Eckhard
Siebeck, Matthias
Gropp, Roswitha
JOURNAL OF TRANSLATIONAL MEDICINE, 2013, 11
[6] Improved function and proliferation of adult human beta cells engrafted in diabetic immunodeficient NOD-scid IL2r gamma (null) mice treated with alogliptin
Jurczyk, Agata
Dilorio, Philip
Brostowin, Dean
Leehy, Linda
Yang, Chaoxing
Urano, Fumihiko
Harlan, David M.
Shultz, Leonard D.
Greiner, Dale L.
Bortell, Rita
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY, 2013, 6 : 493 - 499
[7] NOD-scid IL2rγnull Mouse Model of Human Skin Transplantation and Allograft Rejection
Racki, Waldemar J.
Covassin, Laurence
Brehm, Michael
Pino, Stephen
Ignotz, Ronald
Dunn, Raymond
Laning, Joseph
Graves, Susannah K.
Rossini, Aldo A.
Shultz, Leonard D.
Greiner, Dale L.
TRANSPLANTATION, 2010, 89 (05) : 527 - 536
[8] The differentiative and regenerative properties of human hematopoietic stem/progenitor cells in NOD-SCID/IL2rγnull mice
Ishikawa, F.
Saito, Y.
Yoshida, S.
Harada, M.
Shultz, L. D.
HUMANIZED MICE, 2008, 324 : 87 - 94
[9] Induction of oxazolone-mediated features of atopic dermatitis in NOD-scid IL2Rγnull mice engrafted with human peripheral blood mononuclear cells
Nolte, Thomas
Zadeh-Khorasani, Maryam
Safarov, Orkhan
Rueff, Franziska
Varga, Rita
Herbach, Nadja
Wanke, Ruediger
Wollenberg, Andreas
Mueller, Thomas
Gropp, Roswitha
Wolf, Eckhard
Siebeck, Matthias
DISEASE MODELS & MECHANISMS, 2013, 6 (01) : 125 - 134
[10] Human Nasal Polyp Microenvironments Maintained in a Viable and Functional State as Xenografts in NOD-scid IL2rγnull Mice
Bernstein, Joel M.
Brooks, Stephen P.
Lehman, Heather K.
Pope, Liza
Sands, Amy
Shultz, Leonard D.
Bankert, Richard B.
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, 2009, 118 (12): : 866 - 875

← 1 2 3 4 5 →