Cellular senescence: at the nexus between ageing and diabetes

被引：217
|
作者：
Palmer, Allyson K. [1 ]
Gustafson, Birgit [2 ,3 ]
Kirkland, James L. [1 ]
Smith, Ulf [2 ,3 ]
机构：
[1] Mayo Clin, Robert & Arlene Kogod Ctr Aging, 200 1st St SW, Rochester, MN USA
[2] Sahlgrens Univ Hosp, Dept Mol & Clin Med, Lundberg Lab Diabet Res, S-41345 Gothenburg, Sweden
[3] Univ Gothenburg, S-41345 Gothenburg, Sweden
来源：
DIABETOLOGIA | 2019年 / 62卷 / 10期
基金：
瑞典研究理事会;
关键词：
Ageing; Cellular senescence; Dasatinib; Diabetes; Geroscience; Life course development; Quercetin; Review; Senolytics; Type; 2; diabetes; ADIPOSE-TISSUE; SECRETORY PHENOTYPE; OBESITY; AGE; DIFFERENTIATION; INTERVENTIONS; ADIPOGENESIS; ACTIVATION; DISEASE; CELLS;
D O I：
10.1007/s00125-019-4934-x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Ageing and diabetes lead to similar organ dysfunction that is driven by parallel molecular mechanisms, one of which is cellular senescence. The abundance of senescent cells in various tissues increases with age, obesity and diabetes. Senescent cells have been directly implicated in the generation of insulin resistance. Recently, drugs that preferentially target senescent cells, known as senolytics, have been described and recently entered clinical trials. In this review, we explore the biological links between ageing and diabetes, specifically focusing on cellular senescence. We summarise the current data on cellular senescence in key target tissues associated with the development and clinical phenotypes of type 2 diabetes and discuss the therapeutic potential of targeting cellular senescence in diabetes.
引用
收藏
页码：1835 / 1841
页数：7
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