Role of neurotrophin receptor p75NTR in mediating neuronal cell death following injury

被引：14

作者：

Coulson, EJ

Reid, K

Murray, SS

Cheema, SS

Bartlett, PF ^{[1
]}

机构：

[1] Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

[2] Monash Univ, Dept Anat, Clayton, Vic 3168, Australia

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 2000年 / 27卷 / 07期

关键词：

antisense oligonucleotides; apoptosis; axotomy; Bcl-2; Bcl-x(L); death domain; motor neuron; nerve growth factor; neurotrophin; p75NTR;

D O I：

10.1046/j.1440-1681.2000.03295.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The neurotrophin receptor p75NTR has been shown to mediate neuronal cell death after nerve injury. 2. Down-regulation of p75NTR by antisense oligonucleotides is able to inhibit both sensory and motor neuron death and this treatment is more effective than treatment with growth factors. 3. p75NTR induces cell death by a unique death signalling pathway involving transcription factors (nuclear factor kappa B and c-jun), Bcl-2 family members and caspases.

引用

页码：537 / 541

页数：5

共 50 条

[21] Glucose homeostasis and p75NTR The sweet side of neurotrophin receptor signaling
Baeza-Raja, Bernat
Akassoglou, Katerina
[J]. CELL CYCLE, 2012, 11 (17) : 3151 - 3152
[22] p75NTR and hypoxia A breath of fresh air in neurotrophin receptor signaling
Le Moan, Natacha
Baeza-Raja, Bernat
Akassoglou, Katerina
[J]. CELL CYCLE, 2012, 11 (05) : 829 - 830
[23] Generation of Mice With a Conditional Allele for the p75NTR Neurotrophin Receptor Gene
Bogenmann, Emil
Thomas, Penny S.
Li, Qianfeng
Kim, Jieun
Yang, Liang-Tung
Pierchala, Brian
Kaartinen, Vesa
[J]. GENESIS, 2011, 49 (11) : 862 - 869
[24] The role of p75NTR in modulating neurotrophin survival effects in developing motoneurons
Wiese, S
Metzger, F
Holtmann, B
Sendtner, M
[J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 1999, 11 (05) : 1668 - 1676
[25] Immunohistochemical location of the p75 neurotrophin receptor (p75NTR) in oral leukoplakia and oral squamous cell carcinoma
Takahiro Kiyosue
Shintaro Kawano
Ryota Matsubara
Yuichi Goto
Mitsuhiro Hirano
Teppei Jinno
Takeshi Toyoshima
Ryoji Kitamura
Kazunari Oobu
Seiji Nakamura
[J]. International Journal of Clinical Oncology, 2013, 18 : 154 - 163
[26] A role for inflammatory mediators in the modulation of the neurotrophin receptor p75NTR on human muscle precursor cells
Colombo, Emanuela
Romaggi, Stefania
Mora, Marina
Morandi, Lucia
Farina, Cinthia
[J]. JOURNAL OF NEUROIMMUNOLOGY, 2012, 243 (1-2) : 100 - 102
[27] Immunohistochemical location of the p75 neurotrophin receptor (p75NTR) in oral leukoplakia and oral squamous cell carcinoma
Kiyosue, Takahiro
Kawano, Shintaro
Matsubara, Ryota
Goto, Yuichi
Hirano, Mitsuhiro
Jinno, Teppei
Toyoshima, Takeshi
Kitamura, Ryoji
Oobu, Kazunari
Nakamura, Seiji
[J]. INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 2013, 18 (01) : 154 - 163
[28] Cell autonomous and cell non-autonomous roles of p75 neurotrophin receptor (p75NTR) in glioma invasion
Alshehri, Mana
Ahn, Bo Young
Wang, Xiuling
Tanveer, Shiekh
Chan, Jennifer
Senger, Donna L.
Robbins, Stephen M.
[J]. CANCER RESEARCH, 2015, 75
[29] NGF induces apoptosis in a human neuroblastoma cell line expressing the neurotrophin receptor p75NTR
Kuner, P
Hertel, C
[J]. JOURNAL OF NEUROSCIENCE RESEARCH, 1998, 54 (04) : 465 - 474
[30] The p75NTR neurotrophin receptor is a tumor suppressor in human and murine retinoblastoma development
Dimaras, Helen
Gallie, Brenda L.
[J]. INTERNATIONAL JOURNAL OF CANCER, 2008, 122 (09) : 2023 - 2029

← 1 2 3 4 5 →