Role of neurotrophin receptor p75NTR in mediating neuronal cell death following injury

被引：14
|
作者：
Coulson, EJ
Reid, K
Murray, SS
Cheema, SS
Bartlett, PF [1 ]
机构：
[1] Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
[2] Monash Univ, Dept Anat, Clayton, Vic 3168, Australia
来源：
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 2000年 / 27卷 / 07期
关键词：
antisense oligonucleotides; apoptosis; axotomy; Bcl-2; Bcl-x(L); death domain; motor neuron; nerve growth factor; neurotrophin; p75NTR;
D O I：
10.1046/j.1440-1681.2000.03295.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. The neurotrophin receptor p75NTR has been shown to mediate neuronal cell death after nerve injury. 2. Down-regulation of p75NTR by antisense oligonucleotides is able to inhibit both sensory and motor neuron death and this treatment is more effective than treatment with growth factors. 3. p75NTR induces cell death by a unique death signalling pathway involving transcription factors (nuclear factor kappa B and c-jun), Bcl-2 family members and caspases.
引用
收藏
页码：537 / 541
页数：5
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