Induction chemotherapy in locally advanced squamous cell carcinoma of the head and neck

被引：16

作者：

Okano, Susumu ^{[1
]}

Homma, Akihiro ^{[2
,3
]}

Kiyota, Naomi ^{[4
]}

Tahara, Makoto ^{[1
]}

Hanai, Nobuhiro ^{[5
]}

Asakage, Takahiro ^{[6
]}

Matsuura, Kazuto ^{[7
]}

Ogawa, Takenori ^{[8
]}

Saito, Yuki ^{[9
]}

Sano, Daisuke ^{[10
]}

Kodaira, Takeshi ^{[11
]}

Motegi, Atsushi ^{[12
]}

Yasuda, Koichi ^{[3
,13
]}

Takahashi, Shunji ^{[14
]}

Tanaka, Kaoru ^{[15
]}

Onoe, Takuma ^{[16
]}

Yokota, Tomoya ^{[17
]}

Imamura, Yoshinori ^{[4
]}

Ariizumi, Yosuke ^{[6
]}

Akimoto, Tetsuo ^{[12
]}

Hayashi, Ryuichi ^{[7
]}

机构：

[1] Natl Canc Ctr Hosp East, Dept Head & Neck Med Oncol, 6-5-1 Kashiwanoha, Kashiwa, Chiba 2778577, Japan

[2] Hokkaido Univ, Fac Med, Dept Otolaryngol Head & Neck Surg, Sapporo, Hokkaido, Japan

[3] Hokkaido Univ, Grad Sch Med, Sapporo, Hokkaido, Japan

[4] Kobe Univ Hosp, Canc Ctr, Dept Med Oncol & Hematol, Kobe, Hyogo, Japan

[5] Aichi Canc Ctr Hosp, Dept Head & Neck Surg, Nagoya, Aichi, Japan

[6] Tokyo Med & Dent Univ, Dept Head & Neck Surg, Bunkyo Ku, Tokyo, Japan

[7] Natl Canc Ctr Hosp East, Dept Head & Neck Surg, Kashiwa, Chiba, Japan

[8] Gifu Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Gifu, Gifu, Japan

[9] Univ Tokyo, Dept Otolaryngol & Head & Neck Surg, Bunkyo Ku, Tokyo, Japan

[10] Yokohama City Univ, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Yokohama, Kanagawa, Japan

[11] Aichi Canc Ctr Hosp, Dept Radiat Oncol, Nagoya, Aichi, Japan

[12] Natl Canc Ctr Hosp East, Dept Radiat Oncol, Kashiwa, Chiba, Japan

[13] Hokkaido Univ, Fac Med, Dept Radiat Oncol, Sapporo, Hokkaido, Japan

[14] Canc Inst Hosp, Dept Med Oncol, Tokyo, Japan

[15] Kindai Univ, Dept Med Oncol, Fac Med, Sayama, Osaka, Japan

[16] Hyogo Canc Ctr, Dept Med Oncol, Akashi, Hyogo, Japan

[17] Shizuoka Canc Ctr, Div Gastrointestinal Oncol, Shizuoka, Japan

来源：

JAPANESE JOURNAL OF CLINICAL ONCOLOGY | 2021年 / 51卷 / 02期

关键词：

squamous cell carcinoma; head and neck; induction; chemotherapy; organ preservation; PHASE-III TRIAL; CONCURRENT CHEMORADIOTHERAPY; LARYNX PRESERVATION; UNRESECTABLE HEAD; RANDOMIZED-TRIAL; CANCER; CISPLATIN; FLUOROURACIL; DOCETAXEL; RADIATION;

D O I：

10.1093/jjco/hyaa220

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In order to maximize the benefit of induction chemotherapy, practice based on a comprehensive interpretation of a large number of clinical trials, as in this review, is essential. The standard treatment for locally advanced squamous cell carcinoma of the head and neck is surgery or chemoradiation. However, induction chemotherapy followed by (chemo) radiotherapy may be used in some circumstances. Although many clinical trials of induction chemotherapy have been conducted, a rationale other than to preserve the larynx is still controversial. Selection of this modality should therefore be made with care. The current standard regimen for induction chemotherapy is docetaxel, cisplatin and 5-FU, but concerns remain about toxicity, cost and the duration of treatment. Regarding treatment after induction chemotherapy, it is also unclear whether radiation alone or chemoradiation is the better option. Furthermore, there is no answer as to what drugs should be used in combination with radiation therapy after induction chemotherapy. Several new induction chemotherapy treatment developments are currently underway, and future developments are expected. This review article summarizes the current position of induction chemotherapy for head and neck squamous cell carcinoma, based on the evidence produced to date, and discusses the future prospects for this treatment.

引用

页码：173 / 179

页数：7

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