Analysis of particle coating by spouted bed process

被引:19
|
作者
deOliveira, WP [1 ]
Freire, JT [1 ]
Coury, JR [1 ]
机构
[1] UFSCAR,DEPT CHEM ENGN,BR-13565905 SAO CARLOS,SP,BRAZIL
基金
巴西圣保罗研究基金会;
关键词
coating; kinetics of growth; spouted beds;
D O I
10.1016/S0378-5173(97)00181-6
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The coating of nearly spherical porous alumina with a mean diameter, <(d)over bar (p)>, of 3.9 mm, with a suspension of sucrose and talc in water, was carried out in a conical-cylindrical spouted bed. The rate of increase in particle mass, K-1, and the mass fraction of atomized solids incorporated by the particles, eta, were measured as a function of spouting gas temperature, T-gi, mass flow rate of atomized suspension relative to spouting gas, W-s/W-g, and the gas flow rate relative to minimum spouting, Q/Q(ms). The spouting gas temperature was varied between 67 and 83 degrees C, W-s/W-g between 0.00263 to 0.00471, and Q/Q(ms) between 1.5 and 1.7. K-1 and eta were found to be insensitive to T-gi within the studied range; expressions for their dependence on W-s/W-g and Q/Q(ms) were derived. Particle mass increased linearly with the coating time. The final product is uniform in shape and conserves a log-normal particle mass distribution. (C) 1997 Elsevier Science B.V.
引用
收藏
页码:1 / 9
页数:9
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