The In Vitro Elution Characteristics of Vancomycin From Calcium Phosphate-Calcium Sulfate Beads

被引：7

作者：

Scharer, Brandon M. ^{[1
]}

Sanicola, Shawn M. ^{[1
]}

机构：

[1] Wheaton Franciscan Healthcare, Milwaukee, WI 53222 USA

来源：

JOURNAL OF FOOT & ANKLE SURGERY | 2009年 / 48卷 / 05期

关键词：

assay; bone substitute; diabetes; diluent; infection; osteomyelitis; CEMENT;

D O I：

10.1053/j.jfas.2009.05.001

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

The purpose of this study was to determine the elution characteristics of vancomycin when combined with a calcium phosphate-calcium sulfate mixture to form antibiotic beads in an in vitro environment. The beads were placed in phosphate-buffered saline and kept at 36 degrees C for 6 weeks. Three separate assays were undertaken, after which the phosphate-buffered saline was assayed at 24-hour intervals. Elution of the antibiotic was sustained at a gradual rate for 22 days. The amount of vancomycin assayed nearly equaled the calculated amount of antibiotic per bead measured during bead construction. In conclusion, calcium phosphate-calcium sulfate composite beads, when combined with vancomycin, elute vancomycin in a gradual and sustained fashion for 22 days in vitro. Level of Clinical Evidence: 2 (The Journal of Foot & Ankle Surgery 48(5):540-542, 2009)

引用

页码：540 / 542

页数：3

共 50 条

[1] In vitro elution of vancomycin from calcium phosphate cement
Sasaki, T
Ishibashi, Y
Katano, H
Nagumo, A
Toh, S
[J]. JOURNAL OF ARTHROPLASTY, 2005, 20 (08): : 1055 - 1059
[2] In vitro comparison of elution characteristics of vancomycin from calcium phosphate cement and polymethylmethacrylate
Urabe, Ken
Naruse, Kouji
Hattori, Hideki
Hirano, Masahiro
Uchida, Kentaroo
Onuma, Kenji
Park, Hwang Jung
Itoman, Moritoshi
[J]. JOURNAL OF ORTHOPAEDIC SCIENCE, 2009, 14 (06) : 784 - 793
[3] Elution of Clindamycin and Enrofloxacin From Calcium Sulfate Hemihydrate Beads In Vitro
Phillips, Heidi
Boothe, Dawn M.
Bennett, R. Avery
[J]. VETERINARY SURGERY, 2015, 44 (08) : 1003 - 1011
[4] Bone cements in the calcium phosphate-calcium sulfate system
Smirnov, V. V.
Antonova, O. S.
Goldberg, M. A.
Smirnov, S. V.
Shvorneva, L. I.
Egorov, A. A.
Baikin, A. S.
Barinov, S. M.
[J]. DOKLADY CHEMISTRY, 2016, 467 : 136 - 139
[5] Elution characteristics of vancomycin, teicoplanin, gentamicin and clindamycin from calcium sulphate beads
Wichelhaus, TA
Dingeldein, E
Rauschmann, M
Kluge, S
Dieterich, R
Schäfer, V
Brade, V
[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2001, 48 (01) : 117 - 119
[6] In vitro elution of vancomycin from biodegradable osteoconductive calcium phosphate-polycaprolactone composite beads for treatment of osteomyelitis
Makarov, C.
Cohen, V.
Raz-Pasteur, A.
Gotman, I.
[J]. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2014, 62 : 49 - 56
[7] Elution profiles of metronidazole from calcium sulfate beads
Ithisariyanont, Burasarin
Poapolathep, Saranya
Poapolathep, Amnart
Udomkusonsri, Pareeya
[J]. JOURNAL OF VETERINARY SCIENCE, 2023, 24 (06)
[8] Vancomycin-laden calcium phosphate-calcium sulfate composite allows bone formation in a rat infection model
Boyle, K. Keely
Sosa, Branden
Osagie, Liza
Turajane, Kathleen
Bostrom, Mathias P. G.
Yang, Xu
[J]. PLOS ONE, 2019, 14 (09):
[9] Elution of platinum from carboplatin-impregnated calcium sulfate hemihydrate beads in vitro
Tulipan, Rachel J.
Phillips, Heidi
Garrett, Laura D.
Dirikolu, Levent
Mitchell, Mark A.
[J]. AMERICAN JOURNAL OF VETERINARY RESEARCH, 2016, 77 (11) : 1252 - 1257
[10] Synthesis and properties of bone cement materials in the calcium phosphate-calcium sulfate system
Smirnov, V. V.
Goldberg, M. A.
Khairutdinova, D. R.
Antonova, O. S.
Smirnov, S. V.
Konovalov, A. A.
Barinov, S. M.
[J]. INORGANIC MATERIALS, 2017, 53 (10) : 1075 - 1079

← 1 2 3 4 5 →