In vitro elution of vancomycin from calcium phosphate cement

被引：61

作者：

Sasaki, T

Ishibashi, Y

Katano, H

Nagumo, A

Toh, S

机构：

[1] Hirosaki Univ, Sch Med, Dept Orthopaed Surg, Hirosaki, Aomori 0368062, Japan

[2] Hirosaki Mem Hosp, Hirosaki, Aomori, Japan

来源：

JOURNAL OF ARTHROPLASTY | 2005年 / 20卷 / 08期

关键词：

osteomyelitis; prosthesis infection; vancomycin; antibiotic-impregnated bone cement; calcium phosphate cement;

D O I：

10.1016/j.arth.2005.03.035

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Antibiotic-impregnated bone cement beads have become popular for the treatment of osteomyelitis and/or prosthesis infection. However, bone cement has the disadvantage of heating Lip during polymerization of cement. Recently, calcium phosphate cement (CPC) has been used as a bone replacement and augmentation, and it does not hear tip during polymerization. First, we measured the release rate of vancomycin (VCM) from bone cement and CPC impregnated with VCM for 2 weeks in vitro. The mean concentration of VCM for CPC was 62.6 times at 7 days (258 29 vs 4.12 +/- 1.0) and 6.7 times at 13 days (15.5 +/- 5.5 vs 2.3 +/- 0.7). Second, we were Successful in treating 2 cases of osteomyelitis and prosthesis infection with VCM-impregnated CPC. Front this study, we Concluded that VCM-impregnated CPC might be an effective material for the treatment of osteomyelitis and/or prosthesis infection.

引用

页码：1055 / 1059

页数：5

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