Treatment Targets for Right Ventricular Dysfunction in Pulmonary Arterial Hypertension

被引：43
|
作者：
Prisco, Sasha Z. [1 ]
Thenappan, Thenappan [1 ]
Prins, Kurt W. [1 ]
机构：
[1] Univ Minnesota, Lillehei Heart Inst, Dept Med, Cardiovasc Div, Minneapolis, MN 55455 USA
来源：
JACC-BASIC TO TRANSLATIONAL SCIENCE | 2020年 / 5卷 / 12期
基金：
美国国家卫生研究院;
关键词：
clinical trials; pulmonary arterial hypertension; right ventricle; RIGHT HEART-FAILURE; PRESSURE-OVERLOAD; EJECTION FRACTION; EMERGING ROLE; EXERCISE INTOLERANCE; MOLECULAR-MECHANISMS; DOWN-REGULATION; ALPHA-MYOSIN; HYPERTROPHY; RECEPTOR;
D O I：
10.1016/j.jacbts.2020.07.011
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Right ventricle (RV) dysfunction is the strongest predictor of mortality in pulmonary arterial hypertension (PAH), but, at present, there are no therapies directly targeting the failing RV. Although there are shared molecular mechanisms in both RV and left ventricle (LV) dysfunction, there are important differences between the 2 ventricles that may allow for the development of RV-enhancing or RV-directed therapies. In this review, we discuss the current understandings of the dysregutated pathways that promote RV dysfunction, highlight RV-enriched or RV-specific pathways that may be of particular therapeutic value, and summarize recent and ongoing clinical trials that are investigating RV function in PAH. It is hoped that development of RV-targeted therapies will improve quality of life and enhance survival for this deadly disease. (C) 2020 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.
引用
收藏
页码：1244 / 1260
页数：17
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