Effects of pituitary adenylate cyclase-activating polypeptide (PACAP) on cyclic AMP formation in the duck and goose brain

被引:0
|
作者
Nowak, JZ [1 ]
Kuba, K [1 ]
Zawilska, JB [1 ]
机构
[1] Polish Acad Sci, Dept Biogen Amines, PL-90950 Lodz, Poland
关键词
PACAP (pituitary adenylate cyclase-activating polypeptide); PACAP(27); PACAP(38); VIP (vasoactive intestinal polypeptide); cyclic AMP; hypothalamus; cerebral cortex; duck; goose;
D O I
暂无
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Two molecular forms of pituitary adenylate cyclase-activating polypeptide (PACAP), i.e., PACAP(27) and PACAP(38) (0.0001-1 mu M), as well as vasoactive intestinal polypeptide (VIP; 0.1-3 mu M), have been studied for their effects on cyclic AMP formation in the hypothalamus and cerebral cortex of duck and goose, All three peptides concentration-dependently stimulated cyclic AMP production in the tested brain regions of 2-3-weeks-old (young) ducks, with VIP showing at least one order of magnitude weaker activity than PACAP. This characteristics suggests the existence in the duck's brain of adenylyl cyclase-linked PAC(1) receptors. Both forms of PACAP also stimulated the nucleotide formation in the cerebral cortex and hypothalamus of 5-6-months-old (adult) ducks or geese grown under natural environment. The peptides-evoked effects in adult and young ducks were comparable, and clearly greater than those found in adult geese. The present data extend our recent observations made on chicks, and suggest PACAP to be a potent stimulator of the cyclic AMP generation in the avian central nervous system.
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页码:209 / 214
页数:6
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