Two molecular forms of pituitary adenylate cyclase-activating polypeptide (PACAP), i.e., PACAP(27) and PACAP(38) (0.0001-1 mu M), as well as vasoactive intestinal polypeptide (VIP; 0.1-3 mu M), have been studied for their effects on cyclic AMP formation in the hypothalamus and cerebral cortex of duck and goose, All three peptides concentration-dependently stimulated cyclic AMP production in the tested brain regions of 2-3-weeks-old (young) ducks, with VIP showing at least one order of magnitude weaker activity than PACAP. This characteristics suggests the existence in the duck's brain of adenylyl cyclase-linked PAC(1) receptors. Both forms of PACAP also stimulated the nucleotide formation in the cerebral cortex and hypothalamus of 5-6-months-old (adult) ducks or geese grown under natural environment. The peptides-evoked effects in adult and young ducks were comparable, and clearly greater than those found in adult geese. The present data extend our recent observations made on chicks, and suggest PACAP to be a potent stimulator of the cyclic AMP generation in the avian central nervous system.
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Kagoshima Univ, Grad Sch Med Dent Sci, Dept Pharmacol, Kagoshima 8908544, JapanKagoshima Univ, Grad Sch Med Dent Sci, Dept Pharmacol, Kagoshima 8908544, Japan
Shimizu, T
Imai, K
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Kagoshima Univ, Grad Sch Med Dent Sci, Dept Pharmacol, Kagoshima 8908544, JapanKagoshima Univ, Grad Sch Med Dent Sci, Dept Pharmacol, Kagoshima 8908544, Japan
Imai, K
Iwatani, N
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Kagoshima Univ, Grad Sch Med Dent Sci, Dept Pharmacol, Kagoshima 8908544, JapanKagoshima Univ, Grad Sch Med Dent Sci, Dept Pharmacol, Kagoshima 8908544, Japan
Iwatani, N
Inoue, K
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Kagoshima Univ, Grad Sch Med Dent Sci, Dept Pharmacol, Kagoshima 8908544, JapanKagoshima Univ, Grad Sch Med Dent Sci, Dept Pharmacol, Kagoshima 8908544, Japan
Inoue, K
Sugawara, H
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Kagoshima Univ, Grad Sch Med Dent Sci, Dept Pharmacol, Kagoshima 8908544, JapanKagoshima Univ, Grad Sch Med Dent Sci, Dept Pharmacol, Kagoshima 8908544, Japan
Sugawara, H
Miyata, A
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Kagoshima Univ, Grad Sch Med Dent Sci, Dept Pharmacol, Kagoshima 8908544, JapanKagoshima Univ, Grad Sch Med Dent Sci, Dept Pharmacol, Kagoshima 8908544, Japan
机构:Univ Rouen, UA CNRS,U413,INSERM,IFRMP 23, Lab Neuroendocrinol Cellulaire & Mol, Inst Federat Rech Multidisciplinaires Peptides, F-76821 Mont St Aignan, France
Gonzalez, BJ
Basille, M
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机构:Univ Rouen, UA CNRS,U413,INSERM,IFRMP 23, Lab Neuroendocrinol Cellulaire & Mol, Inst Federat Rech Multidisciplinaires Peptides, F-76821 Mont St Aignan, France
Basille, M
Vaudry, D
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机构:Univ Rouen, UA CNRS,U413,INSERM,IFRMP 23, Lab Neuroendocrinol Cellulaire & Mol, Inst Federat Rech Multidisciplinaires Peptides, F-76821 Mont St Aignan, France
Vaudry, D
Fournier, A
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机构:Univ Rouen, UA CNRS,U413,INSERM,IFRMP 23, Lab Neuroendocrinol Cellulaire & Mol, Inst Federat Rech Multidisciplinaires Peptides, F-76821 Mont St Aignan, France
Fournier, A
Vaudry, H
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Univ Rouen, UA CNRS,U413,INSERM,IFRMP 23, Lab Neuroendocrinol Cellulaire & Mol, Inst Federat Rech Multidisciplinaires Peptides, F-76821 Mont St Aignan, FranceUniv Rouen, UA CNRS,U413,INSERM,IFRMP 23, Lab Neuroendocrinol Cellulaire & Mol, Inst Federat Rech Multidisciplinaires Peptides, F-76821 Mont St Aignan, France
机构:
Showa Univ, Sch Dent, Dept Oral Anat & Dev Biol, Tokyo 142, Japan
Showa Univ, Sch Med, Dept Anat, Tokyo 142, Japan
St Louis Univ, Sch Med, Ctr Geriatr Res Educ & Clin, Vet Affairs Med Ctr St Louis, St Louis, MO USA
St Louis Univ, Sch Med, Dept Internal Med, St Louis, MO USAShowa Univ, Sch Dent, Dept Oral Anat & Dev Biol, Tokyo 142, Japan
Nonaka, Naoko
Nakamachi, Tomoya
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Showa Univ, Sch Med, Dept Anat, Tokyo 142, JapanShowa Univ, Sch Dent, Dept Oral Anat & Dev Biol, Tokyo 142, Japan
Nakamachi, Tomoya
Shioda, Seiji
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Showa Univ, Sch Med, Dept Anat, Tokyo 142, JapanShowa Univ, Sch Dent, Dept Oral Anat & Dev Biol, Tokyo 142, Japan
Shioda, Seiji
Banks, William A.
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St Louis Univ, Sch Med, Ctr Geriatr Res Educ & Clin, Vet Affairs Med Ctr St Louis, St Louis, MO USA
St Louis Univ, Sch Med, Dept Internal Med, St Louis, MO USAShowa Univ, Sch Dent, Dept Oral Anat & Dev Biol, Tokyo 142, Japan