Regioselective synthesis of 1,2,4-triazol-3(2H)-ones and their 3(2H)-thiones: Kinetic studies and selective pyrolytic deprotection

被引：3

作者：

Al-Awadi, NA ^{[1
]}

Ibrahim, YA ^{[1
]}

Kaul, K ^{[1
]}

Dib, H ^{[1
]}

机构：

[1] Kuwait Univ, Dept Chem, Safat 13060, Kuwait

来源：

HETEROATOM CHEMISTRY | 2003年 / 14卷 / 01期

关键词：

D O I：

10.1002/hc.10086

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Selective pyrolytic deprotection of 2-ethyl and 2-cyanoethyl-4-arylidenimino-1,2,4-triazol-3(2H)-ones and their 3(2H)-thiones was studied by flash vacuum pyrolysis. This study is useful in regioselective synthesis of 2- and 4-substituted 1,2,4-triazoles of potential biological applications. The kinetic results and product analysis lend support to a reaction pathway involving a six-membered transition state. (C) 2003 Wiley Periodicals, Inc.

引用

页码：50 / 55

页数：6

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