Regioselective synthesis of 1,2,4-triazol-3(2H)-ones and their 3(2H)-thiones: Kinetic studies and selective pyrolytic deprotection

被引：3
|
作者：
Al-Awadi, NA [1 ]
Ibrahim, YA [1 ]
Kaul, K [1 ]
Dib, H [1 ]
机构：
[1] Kuwait Univ, Dept Chem, Safat 13060, Kuwait
来源：
HETEROATOM CHEMISTRY | 2003年 / 14卷 / 01期
关键词：
D O I：
10.1002/hc.10086
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Selective pyrolytic deprotection of 2-ethyl and 2-cyanoethyl-4-arylidenimino-1,2,4-triazol-3(2H)-ones and their 3(2H)-thiones was studied by flash vacuum pyrolysis. This study is useful in regioselective synthesis of 2- and 4-substituted 1,2,4-triazoles of potential biological applications. The kinetic results and product analysis lend support to a reaction pathway involving a six-membered transition state. (C) 2003 Wiley Periodicals, Inc.
引用
收藏
页码：50 / 55
页数：6
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